Sensorineural hearing loss (SNHL) is a common disability in the world; however, at present, options for the pharmacological treatment of SNHL are very limited. Previous studies involving human temporal bone analyses have revealed that the degeneration of the cochlea is a common mechanism of SNHL. A major problem for the development of novel pharmacotherapy for SNHL has been the limited regenera...

As indicated in Chapter 2 estimates indicate that over 29 million individuals in the U.S. exhibit some degree of sensorineural hearing loss (SNHL) (NIDCD, 2001). It is well accepted that the major sequlae of SNHL is communicative difficulty, particularly in noisy or reverberant listening environments (Crandell, 1991, Crandell and Smaldino, 2000, 2001; Dubno, Dirks, and Morgan, 1984; Killion, 19...

Sensorineural hearing loss (SNHL) is a major pathology of the inner ear that affects nearly 600 million people worldwide. Despite intensive researches, this major health problem remains without satisfactory solutions. The pathophysiological mechanisms involved in SNHL include oxidative stress, excitotoxicity, inflammation, and ischemia, resulting in synaptic loss, axonal degeneration, and apopt...

There are several causes of sensorineural hearing loss (SNHL), in some of which imaging plays an important role for diagnosis and further management. We present an elaborate imaging based pictorial depiction of the various findings in these cases mainly based on CT and MRI imaging.

OBJECTIVE To examine the yield of ophthalmologic examination in the diagnostic workup of unexplained sensorineural hearing loss (SNHL) in children. DESIGN Retrospective analysis of ophthalmologic findings in children with unilateral or bilateral SNHL between January 1998 and May 2000. SETTING Tertiary care university hospital. PARTICIPANTS Children 18 years or younger presenting with unil...

OBJECTIVES To assess the prevalence, characteristics, and risk of sensorineural hearing loss (SNHL) in children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected children. METHODS We included 92 case-patients and 51 controls assessed by using auditory brainstem response and behavioral audiometr...

OBJECTIVES The aim of this study was to investigate changes in the hearing thresholds during the first year of life in infants who failed the newborn hearing screening (NHS) test and of infants treated in the neonatal intensive care unit (NICU). METHODS From March 2007 to November 2010, 193 healthy infants who failed the NHS test and 51 infants who were treated in the NICU were referred for e...

The understanding of the molecular genetics in sensorineural hearing loss (SNHL) has advanced rapidly during the last decade, but the molecular etiology of hearing impairment in the Portuguese population has not been investigated thoroughly. To provide appropriate genetic testing and counseling to families, we analyzed the whole mitochondrial genome in 95 unrelated children with SNHL (53 nonsyn...