Clinical resistance to the induction of experimental allergic encephalomyelitis was observed in a closed colony of Lewis (designated Le-R) rats. Disease susceptibility in randomly bred animals appeared to increase with increasing age. In the small group of young Le-R rats, which were susceptible, disease onset was delayed, severity of symptoms was reduced, and duration of clinical signs was abb...

We have previously demonstrated that exposure to diesel exhaust particles (DEP) prior to ovalbumin (OVA) sensitization in rats reduced OVA-induced airway inflammation. In the present study, Brown Norway rats were first sensitized to OVA (42.3 +/- 5.7 mg/m3) for 30 min on days 1, 8, and 15, then exposed to filtered air or DEP (22.7 +/- 2.5 mg/m3) for 4 h/day on days 24-28, and challenged with OV...

Repeated use of drugs of abuse induces permanent changes in the brain that together with environmental factors can promote the development of addiction. Addiction to alcohol or drugs is a chronic disease that is characterized by a compulsion to seek and take the drug, loss of control in limiting intake, continued use despite obvious harm, and recurrent relapses. Behavioral animal models of addi...

There have been many reports which suggest the presence of tumor specific antigens. Their precise localization and chemical nature are, however, unfortunately obscure. As the tumor cells are arisen from the corresponding normal cells by unknown process of malignnant transformation, their antigenicity is usually extremely weak. The immune reactions to weak antigens, such as antigens of transplan...

METHOD Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT/A or isotonic saline solution. The clinical response was assessed with the -20°C test. Animals that underwent nerve constriction developed sensitization; the sham grou...

P REFORMED antibodies (Abs) in the blood circulation of recipients before transplantation have been identified as the cause of hyperacute rejection (HAR) of the grafts. 1.2 However, liver allografts are relatively resistant to preformed Abs, and because of conflicting results in clinical practice with sensitized recipients, 3 the practical significance of lymphocytotoxic antibodies (LAbs) in an...