1,2,3-Thiadiazole, 1,2,3-selenadiazole, and semicarbazones that are prepared from ketones promising moieties for lead compound development. New 1,2,3-thiadiazole (2c-4c) 1,2,3-selenadiazole derivatives (2d–4d) were the corresponding (2b-4b). The (2b-4b) (2a-4a). Characterization of synthesized compounds was performed using infrared spectra (IR), proton nuclear magnetic resonance (1H-NMR) spectr...

INTRODUCTION The incidence of microbial infections have been increasing day by day in worldwide. Many antibacterial agents are in use against a wide range of infectious diseases1,2. However, the resistance to existing drugs is still a serious problem threat to global public health. This situation leads medicinal chemists to investigate newly synthesized more potent antimicrobial drugs3. Among m...

Background Being a disabling symptom of many medical conditions, effective pain control is one of the most important therapeutic priorities. Morphine and other opioid drugs produce analgesia primarily through μ opioid (MOP) receptors, which mediate beneficial but also the nonbeneficial actions. Appropriate identification of novel opioid analgesics may reduce complications and improve patient co...

Two-dimensional thin-layer chromatography was used to resolve cyclophosphamide metabolites present (a) in blood and urine of cyclophosphamide-treated rats and (b) after incuba tion of cyclophosphamide with hepatic microsomes, a hepatic 9000 X g supernatant fraction, or a model oxygenase system. Incubation of cyclophosphamide with rat hepatic microsomes yielded a single metabolite (aldophosphami...