نتایج جستجو برای: secreted frizzled

تعداد نتایج: 41281  

Journal: :The international journal of biochemistry & cell biology 2015
Vanathi Perumal Kannan Krishnan Enrico Gratton Arun M Dharmarajan Simon A Fox

The Wnts are secreted, lipidated glycoproteins that play a role in cellular processes of differentiation, proliferation, migration, survival, polarity and stem cell self-renewal. The majority of Wnts biological effects are through binding to specific frizzled (Fzd) receptor complexes leading to activation of downstream pathways. Secreted frizzled-related proteins (sFRPs) were first identified a...

Journal: :Annals of the New York Academy of Sciences 2006
Toshio Matsumoto Masahiro Abe

Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. MM cells enhance bone resorption by triggering a coordinated increase in RANK ligand and decrease in osteoprotegerin in the bone marrow. Macrophage inflammatory protein (MIP)-1alpha and (MIP)-1beta are secreted by MM cells, and play a major role in the enha...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
H S Melkonyan W C Chang J P Shapiro M Mahadevappa P A Fitzpatrick M C Kiefer L D Tomei S R Umansky

Quiescent mouse embryonic C3H/10T1/2 cells are more resistant to different proapoptotic stimuli than are these cells in the exponential phase of growth. However, the exponentially growing 10T1/2 cells are resistant to inhibitors of RNA or protein synthesis, whereas quiescent cells die upon these treatments. Conditioned medium from quiescent 10T1/2 cells possesses anti-apoptotic activity, sugges...

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