OBJECTIVE The study was designed to test the efficacy of ATX-MS-1467 in a relevant preclinical model and to assess its safety for the treatment of patients with secondary progressive multiple sclerosis (SPMS). METHODS ATX-MS-1467 was tested for its ability to suppress experimental autoimmune encephalomyelitis (EAE) in the (Ob x DR2)F1 mouse both before and after disease onset. Safety was asse...

Inflammatory-mediated demyelination of the central nervous system with well-recognized axonal injury has been described for over a hundred years. Yet, many pathologic aspects of multiple sclerosis remain poorly understood (Noseworthy et al., 2000). Clinically, a high proportion of patients with relapsing–remitting disease advance to the secondary progressive stage of the disease (Lublin and Rei...

tuberculoma is one of the causes of the space occupying lesions in brain. its manifestations can mimic many diseases such as tumor, vasculitis, and multiple sclerosis.a patient with brain tuberculoma secondary to epidymitis is reported. his symptoms and signs were verysimilar to the patients with multiple sclerosis. the physicians must keep in mind this disease in the differentialdiagnosis with...