background human telomerase reverse transcriptase (htert) has become an ideal target for development of anticancer therapy. small interfering rnas (sirnas) are very powerful reagents for gene silencing and show promise for cancer gene therapy. however, only a small number of sirnas have been demonstrated to be effective. for gene therapy targeting htert, it is essential to develop a robust syst...

There were many occupational toxins for central nervous system and peripheral nervous system such as toxic and heavy metals. The aim of this study was introduction of occupational toxins with neurological effects and inflammatory effects specially. It is a review article. Researcher found the important data about the occupational toxins for nervous systems. Author searched in related journals, ...

<sec>The degradation or failure caused by thermal stress is a serious problem for solid oxide fuel cell (SOFC), especially in preheating process. The common working temperature SOFC more than 700 ℃, so it should be preheated to startup (e.g. 600 ℃). induced gradient crucial factor that results the of SOFC, therefore there are many studies on optimization process.</sec><sec>Num...

Objective To explore changes in the first clinic visits adolescents diagnosed with mood disorders, anxiety or childhood disorders from January 2019 to May 2022 based on outpatient records a large psychiatric hospital China. Methods The medical of aged 12–17 years at their were collected Ningbo Kangning Hospital. Adolescents primarily affective i...

Background: K+ channel toxins are essential tools for the first purifications, analysis of subunit structures and brain localization of voltage-gated K+ (Kv) channels. The effects of a lot of toxins on Kv are not fully known. Methods: Using whole-cell patch clamping technique the action of a series of toxins on Kv3.4 current in rat liver cells with expressed Kv3.4 channels (RLE) cloned cells wa...

<sec>Polymer bonded explosive (PBX) is a kind of composite material with highly filled molding particles (normally more than 95%) and small quantity binders (less 5%). The effective detection internal cracks in PBX great significance evaluating structural integrity safety reliability .</sec><sec>Ultrasonic phased array imaging methods show advantages potential detecting crack ...

among the therapeutic options for achalasia are pneumatic dilatation (pd), an appropriate long-term therapy, and botulinum toxin injection (bt) that is a relatively short-term therapy. this study aimed to compare therapeutic effect of repetitive pneumatic dilation with a combined method (botulinum toxin injection and pneumatic dilation) in a group of achalasia patients who are low responder to ...