Secondary lymphedema is a common postcancer treatment complication, but the underlying pathological processes are poorly understood and no curative treatment exists. To investigate lymphedema pathomechanisms, a top-down approach was applied, using genomic data and validating the role of a single target. RNA sequencing of lymphedematous mouse skin indicated upregulation of many T cell-related ne...

BACKGROUND Lymphedema can cause significant physical impairment and quality-of-life issues. Yet there is a gap in knowledge about lymphedema among breast cancer survivors (BCS), and health care professionals (HCP). Ethnodrama is an innovative knowledge translation strategy that uses theatrical performances for dissemination of research results. We evaluated the impact of live ethnodrama on HCP'...

HYPOTHESIS The causes and management of lower limb lymphedema in the Western population are different from those in the developing world. OBJECTIVE To look at the differential diagnosis, methods of investigation, and available treatments for lower limb lymphedema in the West. DATA SOURCE A PubMed search was conducted for the years 1980-2002 with the keyword "lymphedema." English language an...

OBJECTIVE Lower extremity lymphedema adversely affects quality of life by causing discomfort, impaired mobility and increased risk of infection. The goal of this study is to investigate factors that influence the likelihood of lymphedema in patients with endometrial cancer who undergo adjuvant radiation with or without chemotherapy. METHODS A retrospective chart review identified all stage I-...

Debulking procedures have been a last-resort therapy for end-stage lymphedema more than century. Multiple techniques described, and the approach as whole has fallen in out of favor providers tried to maximize quality life outcomes. We describe our technique radical debulking lower extremity treatment severe lymphedema.

Lymphedema is a common clinical problem. Filariasis is the commonest cause of lymphedema in India and is a chronic debilitating disease. The purpose of this study is to highlight the role of lymphoscintigraphy in the evaluation of lymphedema. Our study population consisted of 418 patients diagnosed with filarial lymphedema of different clinical stages referred for lymphoscintigraphy of the limb...

Background In 1994 the WHO showed about 140 millions cases of lymphedema (Table 1). Italian epidemiological studies report that primary lymphedema are more frequent than secondary. The localization of upper limbs recognizes secondary lymphedema; the primary ones can be located in lower limbs. 30-40 y.o. women are more exposed. In geriatric patients lymphedema is generally secondary and concerne...

Lymphaticovenous anastomosis (LVA) is primarily performed for lymphedema of the lower extremities after surgical treatment of gynecologic cancer and lymphedema of the upper extremities after surgical resection of breast cancer; however, LVA for lymphedema due to malignant lymphoma has not been reported to date. We herein present a patient with severe lymphedema of the lower extremities due to r...

INTRODUCTION Secondary lymphedema is one of the major important long-term complications of breast cancer treatment. The aim of this study is to determine patient- and treatment-related risk factors of lymphedema in breast cancer patients. PATIENTS AND METHODS Patients, who had been operated on for primary breast cancer at Akdeniz University Hospital and followed regularly between August 1984 ...

A 78-year-old man presented to our wound clinic with bilateral lower-extremity weeping ulcerations. He had been diagnosed with lymphedema 5 years previously after sigmoidectomy for obstructing adenocarcinoma. Intraoperatively, there was no evidence of gross adenopathy or metastasis. He declined further treatment or imaging at that time, and was noncompliant with lymphedema therapy. His medical ...