نتایج جستجو برای: scorpion toxin

تعداد نتایج: 53607  

Journal: :Journal of the American Chemical Society 2008

Journal: :archives of razi institute 0
a. zare mirakabadi

scorpionism is a known significant problem of medical and social importance in many tropical and subtropical regions including the middle east. in iran, highest prevalence of scorpion sting about 60% of all the stings has been reported from khuzestan province. among the 21,000 cases of reported scorpion stung patients, 12% were caused by h. lepturus, but contributed to 95% of all moralities in ...

Journal: :archives of razi institute 2016
a. zare mirakabadi

scorpionism is a known significant problem of medical and social importance in many tropical and subtropical regions including the middle east. in iran, highest prevalence of scorpion sting about 60% of all the stings has been reported from khuzestan province. among the 21,000 cases of reported scorpion stung patients, 12% were caused by h. lepturus, but contributed to 95% of all moralities in ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1989
W J Thomsen W A Catterall

Site-directed and monoclonal antibodies recognizing different extracellular regions of the RII sodium channel alpha subunit have been used to determine the sequences that comprise the receptor for alpha-scorpion toxins by evaluating the effect of antibody on voltage-dependent binding of radio-labeled toxin isolated from Leiurus quinquestriatus to both reconstituted rat brain sodium channel and ...

A. Zare Mirakabadi

Scorpionism is a known significant problem of medical and social importance in many tropical and subtropical regions including the Middle East. In Iran, highest prevalence of scorpion sting about 60% of all the stings has been reported from Khuzestan province. Among the 21,000 cases of reported scorpion stung patients, 12% were caused by H. lepturus, but contributed to 95% of all moralities in ...

Journal: :The Journal of General Physiology 2001
Haijun Chen Stefan H. Heinemann

The effects of the scorpion alpha-toxins Lqh II, Lqh III, and LqhalphaIT on human cardiac sodium channels (hH1), which were expressed in human embryonic kidney (HEK) 293 cells, were investigated. The toxins removed fast inactivation with EC(50) values of <2.5 nM (Lqh III), 12 nM (Lqh II), and 33 nM (LqhalphaIT). Association and dissociation rates of Lqh III were much slower than those of Lqh II...

Journal: :The Biochemical journal 1996
B Becerril M Corona F I Coronas F Zamudio E S Calderon-Aranda P L Fletcher B M Martin L D Possani

Seven toxic peptides from the venom of Tityus bahiensis and Tityus stigmurus was isolated and sequenced, five of them to completion. The most abundant peptide from each of these two species of scorpion was 95% identical with that of toxin gamma from the venom of Tityus serrulatus. They were consequently named gamma-b and gamma-st respectively. The genes encoding these new gamma-like peptides we...

Journal: :Molecular pharmacology 2006
Enrico Leipold Alfred Hansel Adolfo Borges Stefan H Heinemann

Voltage-gated sodium (Nav) channels are modulated by a variety of specific neurotoxins. Scorpion beta-toxins affect the voltage-dependence of channel gating: In their presence, Nav channels activate at subthreshold membrane voltages. Previous mutagenesis studies have revealed that the beta-toxin Css4 interacts with the extracellular linker between segments 3 and 4 in domain 2 of Nav channels wi...

ژورنال: پژوهش در پزشکی 2014
تمدن, هانیه, جان احمدی, مهیار, قاسمی, زهرا, وطن پور, حسین,

Abstract Background: Understanding the electrophysiological effects of toxins, may facilitate new drugs discovery. Buthotusschach (BS) has been shown to be one of the most dangerous scorpions in tropical part of Iran. Present study was aimed to investigate the electrophysiological effects of two active fractions (F4 and F6) isolated from BS scorpion toxin on action potential (AP) characteristic...

2013
Kenton J Swartz

The structure of a complex containing a toxin bound to a potassium ion channel has been solved for the first time, revealing how scorpions have designed toxins that can recognize and target the filter that controls the movement of potassium ions through these channels.

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