Uveal effusion syndrome (UES) was reported by Schepens and Brockhurst in 1963,1 and later described as a nanophthalmic disorderwith a scleral abnormality.2 Gass3 described idiopathicUES and hypothesized that the causewas a congenital anomalyof the sclera and vortex veins that was related to aging, hormonal changes, or impairment of the permeabilityof the sclera.Using histologicalmethods,Trelsta...

BACKGROUND Scleral cross-linking (CXL) is a novel attempt to slow down the axial elongation process in animal eyes. As a natural CXL reagent, genipin would be also effective for the prevention of myopia process. Thus, the present study was designed to evaluate the effects of scleral cross-linking using genipin on the form-deprivation (FD) myopia process of guinea pigs. METHODS Twenty-seven 3-...

PURPOSE To investigate the prevalence of scleral hyaline plaque among older adults in the city of Niterói in southeastern Brazil. A second goal was to assess the correlation between scleral hyaline plaque and several age-related diseases, including eye diseases and systemic diseases. METHODS The study sample comprised 667 participants who were followed for 15 months. The study had a prospecti...

Three cases of pseudomonas endophthalmitis associated with scleral necrosis 3 to 10 years after pterygium excision and beta irradiation are described. The value of prophylactic repair of radiation-induced scleral necrosis and early aggressive management of pseudomonas endophthalmitis are emphasized.

A 45-year-old male patient presented with necrotizing scleritis after 2 weeks of having undergone ptyregium surgery with bare sclera technique. Examination revealed a scleral thinning measuring 3 x 3 mm with anterior chamber inflammation. Lamellar scleral graft was dissected from the donor sclera and trephined to the approximate size of the scleral melt. Edges of the host scleral melt were fres...

PURPOSE The proteoglycans synthesized and accumulated within the adult human sclera (aged 50 to 80 years) were identified by their size, glycosaminoglycan side chains, and core proteins in an effort to characterize the proteoglycan content of the human sclera. METHODS Sclerae, unlabeled, or radiolabeled in organ culture with 35SO4 or 3H-proline, were extracted in 4M guanidine-HCl and separate...

PURPOSE It is proposed that the sclera is a metabolically active and pharmacologically responsive tissue. These studies were undertaken to determine whether prostaglandin exposure can enhance scleral permeability to high-molecular-weight substances. METHODS Topical prostaglandin F2 alpha (PGF2 alpha) was administered to monkeys to determine if this altered the amount of scleral matrix metallo...