background apo-lipoprotein e (apoe) and carnitine palmitoyltransferase1-a (cpt1-a) genes are well known to be involved in the pathophysiology of psychiatric disorders such as schizophrenia but regarding their cpg island methylation status data is sparse. objectives the aims of the current study were to highlight the effect of the promoter “hypermethylation” in the development of scz. patients a...

objective: schizophrenia is a complex widespread neuropsychiatric disorder. this illness encompasses a complex debilitating mental disorder causing illusion, delusion, disturbed relationship, low motivation and decline of emotion. viral infection of the brain including borna disease virus (bdv) may play a role in transient or permanent neurological and behavioral abnormalities. this role of bor...

Background: The negative symptoms of schizophrenia remain a major clinical challenge. Nortriptyline is a serotonin and noradrenalin reuptake inhibitor and belongs to secondary amine tricycles. The aim of this study is to evaluate the effect of nortriptyline on the negative symptoms of schizophrenia. Methods: This study is a six-week randomized placebo-control trial of nortriptyline or placebo a...

schizophrenia is a sophisticated mental disability which has affected nearly1.1% of people all over the world. according to recent researches, the key proteins triggered in the immune system are cytokines which might also be taking part in the pathogenesis of schizophrenia. the aim of this study was to evaluate the relationship between the -1082g/a and +874t/a polymorphisms of il-10 and ifn-γ g...

introduction: patients with schizophrenia characteristically exhibit cognitive deficits. the level of cognitive impairment is found to predict the functional outcome of the illness more strongly than the severity of positive or negative symptoms. the purpose of this study was to assess the efficacy of ondansetron, a 5-ht3 receptor antagonist as an adjuvant agent in the treatment of chronic schi...

objective: this study aimed to investigate the verbal memory and working memory impairment in healthy siblings of patients with schizophrenia.  methods: the purpose of this study was to compare cognitive deficits in siblings of the patients with schizophrenia and control group. a total of 35 unaffected siblings of patients with schizophrenia were selected from the relatives of the patients refe...

objective: although the etiology of schizophrenia is unknown, it has a significant genetic component. ‎a number of studies have indicated that neuregulin-1 (nrg1) gene may play a role in the ‎pathogenesis of schizophrenia. in this study, we examined whether the rs2439272 of nrg1 ‎is associated with schizophrenia and its negative symptoms in an iranian population.‎ method: rs2439272 was genotype...

suppression of akt (protein kinase b) has been implicated in schizophrenia, the effect which has been documented to be reversed by tyrosine phosphatase inhibition. t hus, present study has been designed to study the effect of sodium orthovanadate, a tyrosine phosphatase inhibitor, on protracted methionine administration induced schizophrenia like behavior in rats.   schizophrenia like behavior ...

objective: finding a suitable laboratory test that can diagnose schizophrenia in its early stages could be very important. according to the hypothesis of lack of noradrenalin balance in the brain, it is illustrated that the disorder severity has a negative correlation with the amount of urine noradrenalin metabolite [3-methoxy-4-hydroxy phenyl glycol (mhpg) sulfate]. in this research, instead o...