Scanning Ion Conductance Microscopy, it’s development, design and use are introduced. The theory behind modelling ion current flow into the SICM probe tip and the problems involved with analytically modelling the current flow are then briefly discussed. A numerical simulation using the Finite Difference Method is then used to model the current flow as the microscope probe tip approaches a flat ...

We used the atomic force microscope to manipulate and unfold individual molecules of the titin I27 domain and reconstructed its free energy surface using Jarzynski's equality. The free energy surface for both stretching and unfolding was reconstructed using an exact formula that relates the nonequilibrium work fluctuations to the molecular free energy. In addition, the unfolding free energy bar...

On an AgNO3 crystal, an equilateral or a right-angle triangle-shaped Ag trimer was selectively fabricated through near-field photo-reduction and observed in situ by using an apertured cantilever coupled with an atomic force microscope. By using the different triangle-shaped Ag trimers, irradiation wavelength and polarization dependence of surface-enhanced Raman scattering were investigated.

The glycosylation state of individual antibodies was imaged using an atomic force microscope with a probe modified with lectins and an image acquisition system that permits simultaneous acquisition of sample topography data along with a map of lectin binding sites.

A new model for the flexural vibration of an atomic force microscope cantilever is proposed, and a closed-form expression is derived. The effects of angle, damping and tip moment of inertia on the resonant frequency were analysed. Because the tip is not exactly located at one end of the cantilever, the cantilever is modelled as two beams. The results show that the frequency first increases with...

We present a general solution of hydrodynamic resistance of close-approached slippery surfaces with a nanoasperity or a nanobubble as an idealized roughness effect. Based on Reynolds' lubrication theory and a simple slip boundary condition, the pressure distribution in the thin liquid film is predicted analytically and the total hydrodynamic resistance force at limiting cases are formulated in ...