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coronary heart disease is the leading cause of death and disability in adults. the association between acute coronary syndrom (acs) and elevated serum high sensitivity c-reactive protein (hscrp) suggests that chronic inflammation of the coronary arterial wall may play an important role. a number of drugs used in the treatment of cardiovascular disease reduce serum crp. it* is therefore possible...

gliobalstoma multiforme (gbm) or grade 4 astrocytoma is the most malignant form of primary brain tumor. treatment of glioblastoma is difficult despite of surgery, radiotherapy and chemotherapy. patients with glioblastoma survive for less than 12 months. considering to biology function of glioblastoma, researchers have recently offered new therapeutic approaches such as cannabinoid therapy for g...

the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...

Submit Manuscript | http://medcraveonline.com Abbreviations: BBB: Blood-Brain Barrier; CCA: Common Carotid Artery; CIMT: Carotid Intima-Media Thickness; COPD: Chronic Obstructive Pulmonary Disease; FEV1: Forced Expiratory Volume in 1 Second; LDL: Low Density Lipoprotein; MMPS: Matrix Metalloproteinases; SCORE Scale: Scale Of Systematic Coronary Risk Evaluation; TIMPs: Tissue Inhibitors of Matri...

BACKGROUND Co-occurring cognitive impairment in geriatric depression may not improve with antidepressant treatment and it may progress to dementia. AIM Assess the relationship between changes in cognitive and depressive symptoms among patients with geriatric depression and their association with the APOE epsilon 4 allele before and after antidepressant treatment. METHODS The presence of the...

An efficient and rapid affinity-based screening method for directly fishing out natural alpha-glucosidase inhibitors from Cyperus. rotundus extract by using immobilized enzyme technology combined with UHPLC-QTOF MS analysis was established. As a results, without time-consuming and laborious isolation workload and false positive interference, five natural alpha-glucosidase inhibitors were succes...

Background. There are increasing data of targeted therapy efficacy different types Langerhans cell histiocytosis (LCH) with inhibitors BRAF-specific serin-threonine kinase (BRAF-inhibitors) in cases BRAF V600E mutation published last years. At the same time there no use MAPK/ERK pathway (MEK-inhibitors) pediatric patients BRAF-negative forms LCH. Purpose study is to evaluate and safety MEK-inhi...