The proliferation of T-lymphocytes is dependent upon their ability to synthesize and secrete the cytokine, interleukin-2, and to express cell surface receptors for interleukin-2 and transferrin. We have previously reported that certain fatty acids inhibit mitogen-stimulated T-lymphocyte proliferation. We now report that unsaturated fatty acids decrease the concentration of interleukin-2 in the ...

Three groups of Hansenula polymorpha fatty acid auxotrophic mutants were screened by their fatty acid requirement for growth. The mutants are saturated fatty acid auxotrophic mutants (Sfa), monounsaturated fatty acid auxotrophic mutants (Mfa) and polyunsaturated fatty acid auxotrophic mutants (Pfa) which required saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty acids...

The effect of alterations in dietary fat on the serum cholesterol level has been extensively studied during recent years. Numerous investigations have shown reductions in the serum lipid level of man after the dietary substitution of many vegetable oils for common animal fats or certain tropical oils such as coconut oil (1-11). The relatively high degree of saturation of coconut oil and fats of...

Background: Fatty acids are known to be critically important in multiple biological functions. Phospholipid fatty acids of follicular fluid, an important microenvironment for the development of oocytes, may contribute to the women’s fertility and the efficacy of assisted reproduction techniques. The aim of this study was to investigate the effect of fatty acid composition of follicular fluid ph...

The aim of the present study was to determine and compare the seasonal changes in the proximate composition, fatty acids profile and fat soluble vitamins content in spring and autumn goby (Neogobius melanostomus) caught from the Bulgarian Black Sea waters. The proximate composition (moisture, protein and total lipid) has been determined according to AOAC (1990).  Analysis of fatty acid methyl e...

Neutrophil chemiluminescence was determined in patients with active rheumatoid arthritis. Twelve patients were randomly assigned either to a diet high in polyunsaturated fatty acids supplemented with eicosapentaenoic and docosahexaenoic acids or to a diet high in saturated fatty acids. A correlation with clinical and laboratory parameters is also reported. No statistical difference was observed...

Diets rich in polyunsaturated fatty acids lower plasma HDL cholesterol concentrations when compared to diets rich in saturated fatty acids. We investigated the mechanistic basis for this effect in the hamster and sought to determine whether reduced plasma HDL cholesterol concentrations resulting from a high polyunsaturated fat diet are associated with a decrease in reverse cholesterol transport...

Background: Mammalian spermatozoa are characterized by a high proportion of polyunsaturated fatty acids (PUFA) and the membrane structure of spermatozoa plays a crucial role in fertilization. Moreover, dietary fatty acid (FA) influence sperm FA profiles in several species. This study focused on responses to dietary omega-3 fatty acids and comprehensive fatty acid profiles analysis in men as wel...