Trypanosoma cruzi, a hemoflagellate protozoan (family Trypanosomatidae), is the ethiological agent of Chagas disease, which is affecting 16-18 million people, with more than 100 million exposed to the risk of infection. Higher plants are a potential source of new drugs to improve the treatment of Chagase disease. Until recently, Rutacea, Meliaceae, Simaroubaceae and Burceraceae families have be...

background: the study evaluated qualitative pcr, primers 121-122 as a tool to follow up evolution parasite load of trypanosoma cruzi . methods: the study was conducted at the state university of maringa, in 2015. step 1, dilutions 1/10 were performed from t. cruzi -y strain to obtain preparations of 50,000-0.05 parasites/ml from which dna were extracted, quantified, and amplified. step 2, the e...

Paraffin tissue blocks from 27 cases with sporadic myocarditis were collected during a 12-year period at a single medical examiner's office. Blocks were studied by using histopathology; immunohistochemistry for viruses (adenovirus, enterovirus, influenza A and B, and human herpes types 4 and 5), bacteria (Neisseria meningitidis, Ehrlichia sp, spotted fever group Rickettsia) and parasites (Toxop...

the parasites of genus sarcocystis are among the most commonly found parasites in domestic ruminants and some species of sarcocystis can generate important economic loss when causing clinical and subclinical diseases. sarcocystis hominis, one of the three species of sarcocystis that cause muscular cysts in cattle, can infect the human intestinal tract. there is high infection rate of sarcocyst ...

Prevalence of species of Sarcocystis in muscle of 36 caribou, Rangifer tarandus terraenorae, shot in Newfoundland, Canada, was 53%. A greater percentage of infected animals were obtained from the central part of the island. The highest concentration of microscopic sarcocysts, 1/mm2 of tissue, was observed in a 5-year old animal. Although widely distributed throughout the body, cysts were more p...

Partial changes of color (greenish to brownish) were found in prime marbled beef of Japanese black cattle. The disseminated lesions of the skeletal muscles were histopathologically examined in relation to Sarcocystis infection. The lesions in the muscles showed granulomas with inflammatory cell infiltration. The sarcocysts had a distinct wall, which was radically striated by palisading villar p...

Sarcocystis sporocysts from the intestines of 2 opossums (Didelphis albiventris) from Argentina were fed to gamma-interferon knockout (KO) and nude mice. Protozoal schizonts were seen in brain, liver, spleen, and adrenal glands of mice examined 33-64 days after feeding sporocysts. Sarcocysts were seen in skeletal muscles of KO mice 34-71 days after feeding sporocysts. Schizonts and sarcocysts w...

Chagas is a neglected tropical disease caused by the parasite Trypanosoma cruzi with no effective treatment in all its forms. There need to find more therapeutic alternatives reduced toxicity. In this contribution, multiple linear regression models were used identify molecular descriptors that best describe inhibitory activity of 52 fenarimol analogues against cruzi. The topological, physicoche...

  Background: Some of medicinal plants are a potential source of new drugs to improve the treatment of Chagase disease whose treatment is still a challenge. Here in this screening, the in vitro trypanocidal activity of some fractions for 16 medicinal plants, collected from the northern part of Iran, has been reported.   Methods: Aerial parts of the plants were dried carefully and followed by ex...

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