PURPOSE To evaluate the effect of the anti-fibrotic protein serum amyloid P (SAP) on radiation-induced oral mucositis (OM) and fibrosis in a hamster cheek-pouch model. EXPERIMENTAL DESIGN Hamsters received a single dose of radiation (40 Gy) to the left everted cheek pouch to induce significant OM. The protective therapeutic potential of SAP was evaluated using varying dosing regimens. The ext...

Extract from SAP is a leading provider of enterprise application software. Nearly 65 percent of the world’s fi nancial transaction revenue involves SAP software somewhere along the way. Traditionally, SAP’s offerings such as SAP Customer Relationship Management or SAP ERP (SAP Enterprise Resource Planning) have not only been applications, ...

Der Einsatz von SAP-Software in der Lehre wird auch kritisch betrachtet. Dem kann aber durch die Beachtung didaktischer Konzepte begegnet werden. Nach einer kurzen Darstellung des Einsatzes von SAP-Software an der FHTW Berlin wird das Lehrkonzept des Autors anhand der Klassifizierung von fünf Lehrveranstaltungen vorgestellt. Schwerpunkt des Beitrags sind konkrete Beispiele aus den Bereichen SAP...

C-reactive protein (CRP) and serum amyloid P-component (SAP) are two members of a group of plasma proteins termed pentraxins, which are composed of five identical noncovalently linked subunits that display Ca(2+)-dependent binding to a wide variety of substrates. Purified human SAP binds to CRP, only when the latter is immobilized, in a Ca(2+)-dependent manner under physiological conditions. Ex...

The primary manifestation of X-linked lymphoproliferative syndrome, caused by a dysfunctional adapter protein, signaling lymphocyte activation molecule-associated protein (SAP), is an excessive T cell response upon EBV infection. Using the SAP-/- mouse as a model system for the human disease, we compared the response of CD8+ T cells from wild-type (wt) and mutant mice to various stimuli. First,...

Incorporating superabsorbent polymer (SAP), which has the abilities of absorption and desorption in concrete can achieve the effect of internal curing. The influences of the volume, particle size and ways of entrained water of SAP on the workability, compressive strength, shrinkage, carbonation resistance and chloride penetration resistance of concrete were analyzed through the macroscopic and ...

X-linked lymphoproliferative disease (XLP1) arises from mutations in the gene encoding SLAM-associated protein (SAP) and leads to abnormalities of NKT-cell development, NK-cell cytotoxicity, and T-dependent humoral function. Curative treatment is limited to allogeneic hematopoietic stem cell (HSC) transplantation. We tested whether HSC gene therapy could correct the multilineage defects seen in...