oxaliplatin, a third generation of platinum-based anti-neoplastic agent has been approved for colorectal cancer in both adjuvant and metastatic settings. in addition, oxaliplatin is also indicated for other gastrointestinal malignancies such as metastatic pancreatic cancer in combination with gemcitabine. its common toxicities include infusional hypersensitivity reaction (hsr), gi symptoms with...

The reactivity of quinoneimines towards ketene and diphenylketene was examined. N-Phenylbenzoquinoneirnines (I), (2) and also N-phenylnaphthoquinoneimine react with ketene to give the spiro-adducts (5), (7) and (1 1) respectively. These adducts were stable even after prolonged heating in high boiling solvent. Reaction of the above imines with diphenylketene also afforded 13- lactam spiro-a...

the reaction mechanism between (h2c) and (7, 0), zigzag single-walled carbon nanotubes(zswcnts) on two different orientation of c-c have been studied by semi empirical am!method. the activation barriers of (h2c) adding to (7, 0) zswcnt are computed and compared.the effects of diameters of zigzag swcnt on their binding energies were studied

a 47 year-old woman presented with eight-month history of tattoo allergic reaction of eyebrows after botulinum toxin a injection that was resistant to oral, topical and intralesional injection of corticosteroids. multiple sessions of treatment with co2 fractional laser resulted in significant flattening of allergic papules and plaques as well as reduction of tattoo pigmentation

introduction: α-amylase is a major form of amylase found in humans and other mammals. it is the special key enzyme involved in carbohydrates breakdown. inhibition of this enzyme could be used in treatment of diabetes. in this study, the effect of ten iranian macrolichens on alpha amylase were tested. methods: different concentrations of the extracts (25, 50 and 75 mg/ml) were incubated with enz...