نتایج جستجو برای: salt iodination
تعداد نتایج: 80843 فیلتر نتایج به سال:
Iodination of bovine pancreatic ribonuclease A at O” and pH 8.5 leads to the formation of 3 iodinated tyrosyl residues and 1 iodinated histidyl residue. The yield of iodinated amino acids is not significantly different at 24’. Carboxymethylation of histidine-119 reduces the total organic iodine from -8 to -6 g atoms per mole. This decrease is almost entirely accounted for by a lack of iodohisti...
Regioselective palladium catalysed coupling reactions are achieved in good to high yields, starting from either 3,5-dichloro- or 3,5-dibromoisothiazole-4-carbonitriles 1 and 2, providing 3-halo-5-(hetero/aryl, alkenyl and alkynyl)isothiazoles 3, 4, 6-9 from Stille couplings, 3-halo-5-(hetero/arylethynyl)isothiazoles 14-19 from Sonogashira and 5,5'-bi(3-chloroisothiazole-4-carbonitrile) (13) fro...
The first iodinated cyclopentadienone was isolated and its structure was confirmed by single crystal X-ray analysis. Based on this intermediate, the first direct C-C bond formation on cyclopentadienone ring was achieved. The photo induced intramolecular charge transfer of alkynylated cyclopentadienones was evaluated by solvent polarity effect on their electronic absorption spectra.
Although intensively studied, the high-resolution crystal structure of the peptide DFNKF, the core-segment of human calcitonin, has never been described. Here we report how the use of iodination as a strategy to promote crystallisation and facilitate phase determination, allowed us to solve, for the first time, the single-crystal X-ray structure of a DFNKF derivative. Computational studies sugg...
Direct iodination of benzothiazoles under strong oxidative/acidic conditions leads to a mixture iodinated heteroarenes with 1–2 major components, which are easily separable and structures depend on the I2 equivalents used. Among unexpected but dominant products were identified 4,7-diiodobenzothiazoles rare substitution pattern for SEAr reactions this scaffold. These employed in synthesis 4,7-bi...
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