Salivary gland tumors are often considered difficult to diagnose pathologically because of their histological variability and complexity. There were only nine types in the first edition (1972) WHO classification salivary tumors; however, 35 will be adopted 5th (2022). This is mainly due epidemiological data, recognition new concepts, advances immunohistochemistry discovery tumor-specific gene m...

AbstractBackground: Saliva is a biological fluid that has multiple protective functions. These functions can beattained only if the saliva keeps certain physo-chemical properties such as pH.Methods: The main purpose of the current study was to compare the salivary pH among khat chewers and<b...

Introduction: Natural killer (NK) cells, of which CD56 is a specific marker, play an important role in host defense against tumors. Cancer stem cells, of which aldehyde dehydrogenase isoform 1 (ALDH1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. We aimed to evaluate the expression of ALDH1 and CD56 in common salivary g...

Radiotherapy of head and neck cancers often results in collateral damage to adjacent salivary glands associated with clinically significant hyposalivation and xerostomia. Due to the reduced capacity of salivary glands to regenerate, hyposalivation is treated by substitution with artificial saliva, rather than through functional restoration of the glands. During embryogenesis, the ectodysplasin/...

Salivary gland tumors are rare and account for 2-3% of tumors occurring in the head and neck. Pleomorphic adenoma is a benign neoplasm which is commonly encountered in the parotid gland and other major salivary glands. At times they can also develop in minor salivary glands of the palate. The majority of minor salivary gland tumors are malignant. This case report describes a case of mixed tumor...

Dear Editor, Salivary duct carcinomas (SDC) are primarily high-grade, aggressive malignancies that affect men in the fi fth and sixth decades of life. These tumours are primarily found in the major salivary glands, especially parotid and are rarely from minor salivary glands. If it involves the minor salivary gland, the most common reported sites include the paranasal sinuses and intraoral cavi...

Salivary biomarkers have been increasingly popular in stress research as saliva is easily produced and collection is non-invasive and not limited by geographical distance or lack of infrastructure. Several salivary biomarkers have been utilized in stress research, for instance, salivary cortisol, salivary amylase and salivary immunoglobulin A. Despite being sensitive to changes in fatigue, they...

Introduction and objectives: positive correlation have been seen between high salivary calcium content and periodontal disease. This study was designed to compare inorganic salivary calcium, phosphate, flow rate and ph, of paraffin wax stimulated saliva of patients with gingivitis; mild periodontitis; moderate periodontitis; severe periodontitis. Methods: the present study consisted of 125 pati...

Despite a pivotal role in salivary gland development, homeostasis, and disease, the role of salivary gland mesenchyme is not well understood. In this study, we used the Col1a1-GFP mouse model to characterize the salivary gland mesenchyme in vitro and in vivo. The Col1a1-GFP transgene was exclusively expressed in the salivary gland mesenchyme. Ex vivo culture of mixed salivary gland cells in DME...

BACKGROUND Cell growth arrest and autophagy are required for autophagic cell death in Drosophila. Maintenance of growth by expression of either activated Ras, Dp110, or Akt is sufficient to inhibit autophagy and cell death in Drosophila salivary glands, but the mechanism that controls growth arrest is unknown. Although the Warts (Wts) tumor suppressor is a critical regulator of tissue growth in...