to compare the effect of coccidiostate drugs (salinomycin and maduramicin) on the oocyst sheding and performance of coccidi-infected broiler chicken, 180 ross 308 broiler chicken were randomly assigned to four treatments. each treatment contains 3 replacements of 15 chickens. treatment 1 and 2 fed diets supplemented with maduramicin and salinomycin until three days before experiment period, res...

Cancer stem cells represent a small number of pluripotent and self-renewing cells within a tumor, which are resistant to conventional chemotherapy and are responsible for tumor initiation and maintenance. The Wnt/β-catenin signaling pathway drives stem cell self-renewal and is involved in the pathogenesis of various types of cancer. Aberrant activation of the Wnt signaling pathway in normal ste...

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Distal recurrences represent the dominant problem with this disease. Adjuvant chemotherapy has an established benefit but the administration of highly effective chemotherapy regimens has proven difficult. In their manuscript, Barbara Jonchere and colleagues used different colon cancer cell lines with the aim to unveil novel m...

In the course of our studies concerning the derivatization of the polyether ionophore nigericin1'2) we observed a dependence of the antibacterial activity on the counter ion at C-l,3) which prompted us to investigate if related effects can also be found for other polyethers and indications. Salinomycin (1), for example is another important polyether4'5) which is produced in combination with rel...

There is a small proportion of cells within a tumour with self-renewing properties, which is resistant to conventional therapy, and is responsible for tumour initiation, maintenance and metastasis. These cells are known as cancer stem cells (CSCs) or tumour-initiating cells (TICs) [1]. Recent publications identify several antibiotics, such as salinomycin or doxycycline, as selective CSCs inhibi...