Image-guided sensory block and radiofrequency ablation of the nerves innervating the sacro-iliac joint require readily identifiable bony landmarks for accurate needle/electrode placement. Understanding the relative locations of the transverse sacral tubercles along the lateral sacral crest is important for ultrasound guidance, as they demarcate the position of the posterior sacral network (S1-S...

interval estimate s1 s2 s3 s4 s5 s6 A B C D (a) Uniform 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 −3 −2 −1 0 1 2 3 4 O ve rla p fu nc tio n Abstract interval estimate s1 s2 s3 s4 s5 s6interval estimate s1 s2 s3 s4 s5 s6 (b) Gaussian Figure 10: The overlap function for a set of 6 sensors using two distribution models (resolution is 0.05). The integrated information lies within regions over which t...

Voltage-gated potassium (KV) channels are membrane proteins that respond to changes in membrane potential by enabling K+ ion flux across the membrane. Polyunsaturated fatty acids (PUFAs) induce channel opening by modulating the voltage-sensitivity, which can provide effective treatment against refractory epilepsy by means of a ketogenic diet. While PUFAs have been reported to influence the gati...

The voltage-sensing domains in voltage-gated K(+) channels each contain four transmembrane (TM) segments, termed S1 to S4. Previous scanning mutagenesis studies suggest that S1 and S2 are amphipathic membrane spanning alpha-helices that interface directly with the lipid membrane. In contrast, the secondary structure of and/or the environments surrounding S3 and S4 are more complex. For S3, alth...

Prominin-1/CD133 is a five-membrane-span glycoprotein that is thought to act as an organizer of plasma-membrane protrusions. Here, we report the molecular and cell-biological characterization of four novel prominin-1 splice variants isolated from a mouse testis cDNA library and referred to as prominin-1.s3 to prominin-1.s6. Compared with kidney-derived prominin-1.s1, the s3, s4 and s5 variants ...

Malathion in-vitro biodegradation study was conducted in liquid medium with five bacterial strains labeled S1, S2, S3, S4 and S5 isolated from newly reclaimed agricultural soil. Malathion residues were measured at successive intervals until 30 days after incubation, paralleled with control samples. Malathion Recovery rate was performed at 0.1 and one mg kg, achieved values were 91.30 and 98.70%...

Liver fibrosis is a major disease that is primarily caused by hepatitis virus infections, toxins, and alcohol abuse. Diagnosing and staging liver fibrosis are critical in guiding the treatment of chronic liver diseases, according to several international and Chinese guidelines. Liver biopsy is the gold standard for diagnosing and staging liver fibrosis, but it is invasive and suffers from sever...

The activation of Shaker K+ channels is steeply voltage dependent. To determine whether conserved charged amino acids in putative transmembrane segments S2, S3, and S4 contribute to the gating charge of the channel, the total gating charge movement per channel was measured in channels containing neutralization mutations. Of eight residues tested, four contributed significantly to the gating cha...

1. Experimental Procedures S2 2. Figure. S1. Target DNA assay by RCA in vitro. S4 3. Figure. S2. Quantitative detection of the target sequence in vitro. S5 4. Figure. S3. Quantitative detection of real mRNA GAPDH by RCA in vitro. 5. Figure. S4. Identification of RCA amplicons in the fluorescence image. S5 S6 6. Table S1. PAAm Hydrogel mechanical and swelling properties after polymerization of r...