Insulin-like growth factor I (IGF-I) has acute insulin-like metabolic effects and long-term anabolic actions offering a range of important therapeutic applications. To evaluate a system for large-scale production of this peptide in the mammary glands of transgenic livestock, we generated transgenic rabbits carrying fusion genes in which a synthetic DNA coding for human IGF-I (hIGF-I) was placed...

Cone snails (Conus) are predatory marine mollusks that immobilize prey with venom containing 50-200 neurotoxic polypeptides. Most of these polypeptides are small disulfide-rich conotoxins that can be classified into families according to their respective ion-channel targets and patterns of cysteine-cysteine disulfides. Conkunitzin-S1, a potassium-channel pore-blocking toxin isolated from C. str...

BACKGROUND After shocks with an approximately 50% probability of success for the upper limit of vulnerability (ULV(50)) of strength, the first few activations appear focally on the epicardium at almost the same site at the left ventricular (LV) apex in both successful and failed induction of ventricular fibrillation (VF). We tested the hypothesis that subendocardial ablation at this early site ...

Figure S1. EDS spectrum of Ta-doped TiO2 as a function of ratio of cycles of TaOx to TiO2, a) 1:150, b) 1:100, and c) 1:50. d) Atomic percentage of Ta as a function of ratio of cycles of TaOx:TiO2.

The binding curve of myosin subfragment-1 (S1) to F-actin is not a simple hyperbola: at high concentrations of S1 the binding curve can be transformed into a linear plot ("normal" binding), but at small concentrations of S1 the binding complications deform the binding curve and produce nonlinear transforms ("anomalous" binding) [Andreev, O. A., & Borejdo, J. (1992) J. Muscle Res. Cell Motil. 13...

The images for S1 Fig, S2 Fig and S3 Fig are swapped. The image for S1 Fig should be S3 Fig, the image for S2 Fig should be S1 Fig, and the image for S3 Fig should be S2 Fig. Please view the correct Supporting Information Figures below. S1 Fig. Stability of fibrinogen and degradation by plasmin. To assess whether degradation of fibrinogen occurs during prolonged incubation at 37°C, purified fib...