To date, prediction of Alzheimer's disease (AD) is mainly based on clinical criteria because no well-established biochemical biomarkers for routine clinical diagnosis of AD currently exist. We developed an approach to aid in the early diagnosis of AD by using principal component analysis (PCA)-based spectral analysis of oxidized protein electrophoretic profiling. We found that the combination o...

Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease that affects up to 25% of children and 10% of adults. Approximately 90% of patients with AD are colonised by Staphylococcus aureus, compared with only 5–30% of non-atopic individuals. Th2 cytokines have a permissive effect on microbial invasion, the epidermal barrier, and cell-mediated immunity, which lowers the prod...

The goal of this study was to determine the retinal blood flow rate (BFR) and blood flow velocity (BFV) of pre-capillary arterioles and post-capillary venules in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Forty patients (20 AD and 20 MCI) and 21 cognitively normal (CN) controls with a similar age range (± 5 yrs) were recruited. A retinal function imager (RFI) wa...

This report outlines a goal-directed scientific agenda for a national initiative to overcome the Alzheimer's disease (AD) crisis. The statement, which reflects the collective views and recommendations of leaders in AD research, is intended to aid the implementation of the National Alzheimer's Project Act (NAPA)'s National Plan to defeat AD. The primary public policy aims of this 10-year scienti...

Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which severely impacts on the global economic development and healthcare system. Though AD has been studied for more than 100 years since 1906, the exact cause(s) and pathogenic mechanism(s) remain to be clarified. Also, the efficient disease-modifying treatment and ideal diagnostic method for AD are unavailable....

Several magnetic resonance imaging studies have shown that the entorhinal cortex (ERC) is first brain area related to pathologic changes in Alzheimer’s disease (AD), even before atrophy of hippocampus (HP). However, change ERC morphology (thickness, surface and volume) progression from aMCI AD, especially subtypes (single-domain multiple-domain: aMCI-s aMCI-m), however, still unclear. thickness...

Many Alzheimer’s disease (AD) patients suffer from altered cerebral blood flow and damaged vasculature. Cerebrovascular dysfunction could play an important role in this disease. However, the mechanism underlying a vascular contribution AD is still unclear. reactivity (CVR) critical that maintains brain homeostasis. Most current methods to analyze CVR require anesthesia which known hamper invest...

objective: frankincense improves memory in different models of learning. however, its influence on models of alzheimer's disease (ad) has not been studied widely. in the present study, the therapeutic effect of frankincense was evaluated in a model of ad induced by i.c.v administration of streptozotocin. materials and methods: under stereotaxic surgery, two guide cannulas were implanted in...