Using mobile smart devices to provide urban location-based services (LBS) with sub-meter-level accuracy (around 0.5 m) is a major application field for future global navigation satellite system (GNSS) development. Real-time kinematic (RTK) positioning, which is a widely used GNSS-based positioning approach, can improve the accuracy from about 10-20 m (achieved by the standard positioning servic...

Receptor tyrosine kinases (RTK) are therapeutic targets for the treatment of malignancy. However, tumor cells develop resistance to targeted therapies through the activation of parallel signaling cascades. Recent evidence has shown that redundant or compensatory survival signals responsible for resistance are initiated by nontargeted glycoprotein RTKs coexpressed by the cell. We hypothesized th...

Receptor tyrosine kinase (RTK) targeted therapy has been explored for glioblastoma treatment. However, it is unclear which RTK inhibitors are the most effective and there are no predictive biomarkers available. We recently identified the RTK AXL as a putative target for the pan-RTK inhibitors cediranib and sunitinib, which are under clinical trials for glioblastoma patients. Here, we provide ev...

Global Navigation Satellite System Real-time Kinematic (GNSS-RTK) is an indispensable source for the absolute positioning of autonomous systems. Unfortunately, performance GNSS-RTK significantly degraded in urban canyons, due to notorious multipath and Non-Line-of-Sight (NLOS). On contrary, LiDAR/inertial odometry (LIO) can provide locally accurate pose estimation structured scenarios but subje...

Ionospheric Effects on Network-RTK A part of the atmosphere is ionized by the UV radiation from the Sun. This part is often referred to as the ionosphere. The resulting free electrons influence the GNSS signals as they propagate through the ionosphere. We have studied how the spatial variations of electron density in the ionosphere affect measurements with network-RTK. The aim is to predict wha...

Abstract This paper analyzes candidate schemes for PPP/PPP-RTK (precise point positioning/real-time kinematic) data authentication. Asymmetric are proposed based on existing standards and compatible with GNSS messages. Post-quantum cryptographic signatures also reviewed discussed. Two selected analysis: digital signature (DS) ECDSA, delayed disclosure (DD) a hybrid scheme using the TES...

Mouse developmental kinase 4 (MDK4), a novel receptor tyrosine kinase (RTK), was identified via degenerate primer screening of mouse embryo cDNA. The mRNA encoding this RTK was found only in skeletal muscle of mouse embryos and the maternal decidua. Northern blot analysis predicted an mRNA transcript size of 6.1 kb. The amino acid sequence is most closely related to Torpedo RTK. Analysis of mRN...

This study developed a smartphone application that provides wireless communication, NRTIP client, and RTK processing features, and which can simplify the Network RTK-GPS system while reducing the required cost. A determination method for an error model in Network RTK measurements was proposed, considering both random and autocorrelation errors, to accurately calculate the coordinates measured b...

Activating FLT3 mutations are the most common genetic aberrations in acute myeloid leukemia (AML), resulting in the constitutive activation of this receptor tyrosine kinase (RTK), but such mutations are rarely found in acute lymphoblastic leukemia (ALL). Here we describe a unique subset of de novo adult T-cell ALL (T-ALL) cases that coexpress CD117/KIT and cytoplasmic CD3 (CD117/KIT(+) ALL). Ac...

Tyrosine kinases are mainly classified into two groups, as receptor tyrosine kinase (RTK) and non-receptor tyrosine kinase (NRTK). The RTK family of transmembrane ligand-binding proteins are important mediators of the signaling cascade and includes EGFR, PDGFR (platelet-derived growth factor receptors), FGFR (fibroblast growth factor receptor) and the IR (insulin receptor). RTKs comprise 59 mem...