The objective of this research is to compare the cutting parameters of turning operation the work pieces of medium carbon steel (AISI 1045) by finding the longest tool life by Taguchi methods and Response Surface Methodology: RSM. This research is to test the collecting data by Taguchi method. The analyses of the impact among the factors are the depth of cut, cutting speed and feed rate. This r...

In the present work, we reported the enzymatic preparation of deapio-platycodin D (dPD) and platycodin D (PD) optimized by response surface methodology (RSM) from Radix Platycodi. During investigation of the hydrolysis of crude platycosides by various glycoside hydrolases, snailase showed a strong ability to transform deapio-platycoside E (dPE) and platycoside E (PE) into dPD and PD with 100% c...

This paper integrates Nelder–Mead simplex search method (NM) with genetic algorithm (GA) and particle swarm optimization (PSO), respectively, in an attempt to locate the global optimal solutions for the nonlinear continuous variable functions mainly focusing on response surface methodology (RSM). Both the hybrid NM–GA and NM–PSO algorithms incorporate concepts from the NM, GA or PSO, which are ...

A novel expression vector constructed from genes of Pichia pastoris was applied for heterologous gene expression in Saccharomyces cerevisiae. Recombinant streptokinase (SK) was synthesized by cloning the region encoding mature SK under the control of glyceraldehyde 3-phosphate dehydrogenase (GAP) promoter of Pichia pastoris in Saccharomyces cerevisiae. SK was intracellularly expressed constitut...

Various modeling techniques were used to understand fluidized bed granulation using a two-step approach. First, Plackett-Burman design (PBD) was used to identify the high-risk factors. Then, Box-Behnken design (BBD) was used to analyze and optimize those high-risk factors. The relationship between the high-risk input variables (inlet air temperature X1, binder solution rate X3, and binder-to-po...

The aim of this study was obtain a model that maximizes growth and production of inulinase and invertase by Aspergillus niger ATCC 20611, employing response surface methodology (RSM). The RSM with a five-variable and three-level central composite design (CCD) was employed to optimize the medium composition. Results showed that the experimental data could be appropriately fitted into a second-or...

The purpose of this article is to provide a survey of the various stages in the development of response surface methodology (RSM). The coverage of these stages is organized in three parts that describe the evolution of RSM since its introduction in the early 1950s. Part I covers the period, 1951–1975, during which the so-called classical RSM was developed. This includes a review of basic experi...

Xanthomonas oryzae pv. oryzae, the causal agent of bacterial leaf blight in rice, contains a regulator that is encoded in the genome, designated OryR, which belongs to the N-acyl homoserine lactone (AHL)-dependent quorum-sensing LuxR subfamily of proteins. However, we previously reported that X. oryzae pv. oryzae does not make AHLs and does not possess a LuxI-family AHL synthase and that the Or...

Salvianolic acid A (Sal A), an important constituent of Radix Salviae Miltiorrhizae (RSM), is effective for the treatment of myocardial infarction (MI) and coronary heart disease due to its potential in the improvement of acute myocardial ischemia. However, its content is very low in RSM. So it is obvious to find a rich source of Sal A or to improve its content by conversion of other related co...

43 Preliminary proteomics studies (actual data is not given here) between tonic vs. phasic smooth 44 muscles identified three distinct protein spots identified to be those of SM22. The latter was 45 found to be distinctly down regulated in the internal anal sphincter (IAS) vs. rectal smooth 46 muscle (RSM) SMC. The major focus of the present studies was to examine the differential 47 molecular ...