Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease in which the immune system attacks tissues of joints by mistake. Different factors—either genetic or environmental—affect development RA patients. A lot studies aimed to examine associations with this different populations. This research aspires perform a association study between six single-nucleotide polymorphisms (SNPs) a...

objective(s): accumulating evidence has demonstrated that mirnas contribute to various genetic and epigenetic modifications in the pathogenesis of gastric cancer (gc). recent studies focused on the four single nucleotide polymorphisms (snps) of pre-mirnas including rs11614913, rs3746444, rs2910164, and rs2292832. it was suggested that these four snps were significantly associated with the risk ...

BACKGROUND Both genetic polymorphisms and environmental risk factors play important roles in the development of human chronic diseases including lung cancer. This is the first case-control study of interaction between polymorphisms in pre-miRNA genes and cooking oil fume exposure on the risk of lung cancer. METHODS A hospital-based case-control study of 258 cases and 310 controls was conducte...

Immunity and inflammatory pathways are important in the genesis of non-melanoma skin cancers (NMSC). Functional genetic variation in immune modulators has the potential to affect disease etiology. We investigated associations between common variants in two key regulators, MIR146A and RNASEL, and their relation to NMSCs. Using a large population-based case-control study of basal cell (BCC) and s...

A G to C polymorphism (rs2910164) is located within the sequence of miR-146a precursor, which leads to a change from a G:U pair to a C:U mismatch in its stem region. The predicted miR-146a target genes include BRCA1 and BRCA2, which are key breast and ovarian cancer genes. To examine whether rs2910164 plays any role in breast and/or ovarian cancer, we studied associations between this polymorph...

The associations between two common polymorphisms in microRNA genes (miR-146a, dbSNP: rs2910164; miR-196a-2, dbSNP: rs11614913) and gastric cancer risk have frequently been examined; however, the results have often been controversial. This meta-analysis was performed to clarify the association between the two polymorphisms and gastric cancer risk. The literature search primarily utilized PubMed...

BACKGROUND MicroRNA (miRNA) polymorphisms may alter miRNA-related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers; however, few studies have focused on head and neck squamous cell carcinoma (HNSCC) risk. This study aimed to evaluate the associations bet...