Rosai-Dorfman disease (RDD) is a type of sinus histiocytosis. It rare (1:200000), particularly in children and commonly presents with massive, painless usually bilateral cervical lymphadenopathy along fever weight loss. Leukocytosis, elevated erythrocyte sedimentation rate hypergammaglobulinemia are common. A definitive diagnosis can only be made by histological analysis affected lymph nodes. E...

Most cases of Rosai –Dorfman disease present with painless cervical lymphadenopathy. The disease can involve both nodal and extranodal sites, including the skin. It is generally considered a benign, self limited proliferation of histiocytes. Although cutaneous involvement in RDD is common, purely cutaneous disease is rare. It may present at any age and is common in the second decade. Afro – Car...

Rosai–Dorman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), a rare and usually self limiting disease, was originally described by Destombes in 1965. Subsequently; in 1969, it was characterized as a distinct clinicopathological disorder by Rosai and Dorfman. It is a pseudolymphomatous nonneoplastic lymphoproliferative disease of unknown etiology that presen...