The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. We previously identified and partially purified a mammalian Mediator complex from rat liver nuclei (Brower, C.S., Sato, S., Tomomori-Sato, C., Kamura, T., Pause, A., Stearman, R., Klausner, R.D., Malik, S., Lane, W.S., Sorokina, I., Roeder, R.G., Cona...

[1] We evaluate the relative importance of stormtime ring current electrons to protons by calculating the energy content ratio of electrons to protons for typical ring current energies inferred from observations and simulations. We analyze Explorer 45 measurements taken around the minimum Dst(= 171 nT) of the 17 December 1971 storm. We simulate the electron and proton ring current energy conten...

A large body of nonparametric statistical literature is devoted to density estimation. Overviews are given in Silverman (1986) and Izenman (1991). This paper addresses the problem of univariate density estimation in a novel way. Our approach falls in the class of so called projection estimators, introduced by Cencov (1962). The orthonor-mal basis used is a basis of compactly supported wavelets ...

The influence of mass inhomogeneities on the angular size-redshift test is investigated for a large class of flat cosmological models driven by dark energy plus a cold dark matter component. The results are presented in two steps. First, the mass inhomogeneities are modeled by a generalized Zeldovich-Kantowski-Dyer-Roeder (ZKDR) distance which is characterized by a smoothness parameter α(z) and...

We investigate the cosmological test recently proposed by B. Fort, Y. Mellier and M. Dantel-Fort (FMD), where the observed location of the critical line in gravitational lensing is used to determine the cosmological parameters, Ω and λ. Applying this method to the cluster of galaxies Cl0024+1654, FMD obtained a constraint on the cosmological constant, λ > 0.6, assuming the spatially flat univer...

In the cross-striated muscle of the vertebrate, the spontaneous activity is observed only in special experimental conditions, though it is usually observed in the iterative system such as the smooth muscle. On the other hand it was recently found by Fatt and Katz (3) that miniature spontaneous potentials were generated at the motor end plate. It has been noticed by Wakabayashi that the tymbal m...

The magnification of distant sources by galaxy groups, assumed to be isothermal spheres with properties inferred from an extensive survey, are calculated analytically. It is found that in the weak lensing limit the average effect is exactly counteracted by the Dyer-Roeder beam. When applied to Type 1a supernovae brightness, the results were in broad agreement with the numerical computations of ...

Finding an efficient and computationally feasible approach to deal with the curse of high-dimensionality is a daunting challenge faced by modern biological science. The problem becomes even more severe when the interactions are the research focus. To improve the performance of statistical analyses, we propose a sparse and low-rank (SLR) screening based on the combination of a low-rank interacti...

It is generally accepted that the brain can resolve the order of two stimuli that are separated in time by 20-50 ms. This applies to temporal order judgment of two tactile stimuli, delivered one to each hand, as long as the arms are uncrossed. However, crossing the arms caused misreporting (that is, inverting) of the temporal order. The reversal was not due to simple confusion of hands, because...

We investigate the cosmological test recently proposed by B. Fort, Y. Mellier and M. Dantel-Fort (FMD), where the observed location of the critical line in gravitational lensing is used to determine the cosmological parameters, and . Applying this method to the cluster of galaxies Cl0024+1654, FMD obtained a constraint on the cosmological constant, > 0:6, assuming the spatially at universe. It ...