Rho-associated coiled coil containing protein kinase (Rho-kinase or Rock) is a well-defined determinant of actin organization and dynamics in most animal cells characterized to date. One of the primary effectors of Rock is non-muscle myosin II. Activation of Rock results in increased contractility of myosin II and subsequent changes in actin architecture and cell morphology. The regulation of R...

This study investigated the effect of the Rho kinase inhibitor Y-27632 and fasudil on the development of human mesangial cell (HMC) inflammation and fibrosis induced by high glucose and to clarify the contribution of the Rho/ROCK signaling pathway in the pathogenesis of diabetic kidney disease (DKD). High glucose (30 mmol/l) induced the Rho/ROCK signaling pathway. Western blotting was used to d...

Original scientific paper Aiming at answering the questions of wear and failure of hob in the rock breaking process, the rock breaking process was simulated in different broken rock conditions by using finite element method. The relationship between normal force, lateral force, rolling force and time was obtained by rock breaking simulation analysis on the single edge disc cutter. The rock stre...

We describe the design of an acoustic emission (AE) measurement assembly for reliable acquisition of a multi-year timeseries in steep alpine rock-walls. The motivation for collection of these data is to enhance understanding of freezinginduced rock damage. Because measurements in natural rock slopes are challenging, this study investigates technical options suitable to capture AE signals from d...

Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. Introduction: We present preliminary work to characterize surface rock abundance at ExoMars Rover landing site candidates. A challenge in quantifying the a...

We have performed preliminary mapping of the manganese and iron present in a cross-section of a rock varnish from the Cima volcanic flows in the Mojave Desert, California. Rock varnish is a nanostratigraphic deposit found on typically fine-grained rocks in hyper-arid to semi-arid deserts (Figure 1a) [1]. Rock varnish is defined as consisting of about 70% clay particles held together by about 30...

1 Division of Hematology and Oncology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA 2 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA 3 Pathology and Laboratory Medicine Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA 4 Division of Hematology and...

Drilling and blasting have numerous applications in the civil and mining engineering. Due to the two major components of rock masses, namely the intact rock matrix and the discontinuities, their behavior is a complicated process to be analyzed. The purpose of this work is to investigate the effects of the geomechanical and geometrical parameters of rock and discontinuities on the rock mass blas...

Dymond's 1951 compost experiments with filter cake and Langebaan phosphate rock were continued in 1952. Composting increased the citric solubility of the phosphoric oxide in the rock, although not to .the same extent as in the 1951 experiments. Citric solubility decreased with increasing quantities of phosphate rock. Field trials on sugar cane in Natal have been initiated to determine the avail...

Mohammed Siddiqui, Loretta Bradford, Jennifer Kaley, Gina Johnson, Kevin H. Kim, Kristen Addis and Manisha Singh Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; VA, Central Arkansas Veterans Healthcare System, Littl...