Succinyl-CoA synthetase (SCS) carries out the substrate-level phosphorylation of GDP or ADP in the citric acid cycle. A molecular model of the enzyme from Escherichia coli, crystallized in the presence of CoA, has been refined against data collected to 2.3 A resolution. The crystals are of space group P4322, having unit cell dimensions a=b=98.68 A, c=403.76 A and the data set includes the data ...

The T cell antigen receptor complexes expressed on alphabeta and gammadelta T cells differ not only in their respective clonotypic heterodimers but also in the subunit composition of their CD3 complexes. The gammadelta T cell receptors (TCRs) expressed on ex vivo gammadelta T cells lack CD3delta, whereas alphabeta TCRs contain CD3delta. While this result correlates with the phenotype of CD3delt...

The participation of type I IFNs (IFN-I) in NO production and resistance to Trypanosoma cruzi infection was investigated. Adherent cells obtained from the peritoneal cavity of mice infected by the i.p. route produced NO and IFN-I. Synthesis of NO by these cells was partially inhibited by treatment with anti-IFN-alphabeta or anti-TNF-alpha Abs. Compared with susceptible BALB/c mice, peritoneal c...

The T cell receptor (TCR)gammadelta and the pre-TCR promote survival and maturation of early thymocyte precursors. Whether these receptors also influence gammadelta versus alphabeta lineage determination is less clear. We show here that TCRgammadelta gene rearrangements are suppressed in TCRalphabeta transgenic mice when the TCRalphabeta is expressed early in T cell development. This situation ...

CD3gamma and CD3delta are two highly related components of the T cell receptor (TCR)-CD3 complex which is essential for the assembly and signal transduction of the T cell receptor on mature T cells. In gene knockout mice deficient in either CD3delta or CD3gamma, early thymic development mediated by pre-TCR was either undisturbed or severely blocked, respectively, and small numbers of TCR-alphab...

This paper reports on a joint theoretical and experimental study of the Pauli quantum-mechanical stress tensor T_{alphabeta}(x,y) for open two-dimensional chaotic billiards. In the case of a finite current flow through the system the interior wave function is expressed as psi=u+iv . With the assumption that u and v are Gaussian random fields we derive analytic expressions for the statistical di...

let r be an associative ring with unity. an element a in r is said to be r-clean if a = e+r, where e is an idempotent and r is a regular (von neumann) element in r. if every element of r is r-clean, then r is called an r-clean ring. in this paper, we prove that the concepts of clean ring and r-clean ring are equivalent for abelian rings. further we prove that if 0 and 1 are the only idempotents...

let r be an associative ring with unity. an element a in r is said to be r-clean if a = e+r, where e is an idempotent and r is a regular (von neumann) element in r. if every element of r is r-clean, then r is called an r-clean ring. in this paper, we prove that the concepts of clean ring and r-clean ring are equivalent for abelian rings. further we prove that if 0 and 1 are the only idempotents...

RNA-binding proteins act at various stages of gene expression to regulate and fine-tune patterns of mRNA accumulation. One protein in this class is Drosophila Su(s), a nuclear protein that has been previously shown to inhibit the accumulation of mutant transcripts by an unknown mechanism. Here, we have identified several additional RNAs that are downregulated by Su(s). These Su(s) targets inclu...