AIMS The right ventricle (RV) ejects the same volume of blood at the same rate as the left ventricle (LV). Mild LV dysfunction has been demonstrated in Marfan syndrome (MFS). However, little attention has been paid to the functioning of the RV. The aim of this study was to assess RV function in unoperated adult MFS patients. METHODS AND RESULTS In 66 unoperated (15-58 years) MFS patients and ...

Background New recommendations from task force criteria for the diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) include regional right ventricle (RV) akinesia or dyskinesia or dyssynchronous RV contraction associated to RV dilatation or RV dysfunction evaluated by magnetic resonance imaging (MRI) as major diagnostic criteria. However the frequent presentation of ...

BACKGROUND The leading cause of mortality due to pulmonary arterial hypertension (PAH) is failure of the cardiac right ventricle. It has long been hypothesized that during the development of chronic cardiac failure the heart becomes energy deprived, possibly due to shortage of oxygen at the level of cardiomyocyte mitochondria. However, direct evaluation of oxygen tension levels within the in vi...

From the *Departm the Netherlands; y Stanford Universi Pulmonary Divisio Texas; xPulmona University Hospit University of Pe Cardiovascular D #Department of P Brussels, Belgium; Critical Care Med nessee; yyThe Dav Hypertension, Div UCLA Medical C Group, Centre de mologie de Québ Pulmonary Circul Medical Education Care Medicine an wealth University, more, Maryland. Bayer, GlaxoSmith industry advi...

Right ventricular (RV) hypertrophy is characterized by cardiac fibrosis due to endothelial-mesenchymal transition (EndMT) and increased collagen production in pulmonary arterial hypertension (PAH) patients, but the mechanisms for restoring RV function are unclear. Prostanoid agonists are effective vasodilators for PAH treatment that bind selective prostanoid receptors to modulate vascular dilat...

Right ventricular dysfunction represents a common problem in patients with congenital heart defects, such as Tetralogy of Fallot or pulmonary arterial hypertension. Patients with congenital heart defects may present with a pressure or volume overloaded right ventricle (RV) in a bi-ventricular heart or in a single ventricular circulation in which the RV serves as systemic ventricle. Both subsets...

It was with great interest that we read the recent article by Siniawski et al. [1] entitled ”Clinical, haemodynamic and echocardiographic features of early cardiac graft dysfunction” published in the October issue of ”Kardiologia Polska”. They aimed to establish haemodynamic and echocardiographic criteria of early graft failure to define patients who should be considered for assist device suppo...

Background Cardiac MRI is used to measure right ventricular end diastolic volume indexed to body surface area (RVEDVi) and ejection fraction (EF) in the setting of pulmonary insufficiency (PI). There is data describing optimum RVEDVi, in tetralogy of fallot (TOF) patients, to provide a competent pulmonary valve and maintain long term RV function. Pulmonary atresia with intact ventricular septum...

Pulmonary hypertension (PH) is associated with a metabolic shift towards glycolysis in both the right ventricle and lung. This results in increased glucose uptake to compensate for the lower energy yield of glycolysis, which creates a potential for 2-[18F] fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) to be a useful tool in the evaluation of participants with PH. We investig...

Fi uax 1. Apical four-chamber views from preoperative two-dimensional echocardiogram showing dropout of interventriculan/septal echoes (left panel). Peripheral venous D5W injection (middle panel) at first opacifles only right atrium and ventricle, with no right-to-left shunt and possible left-to-right shunt as indicated by negative contrast effect in the right ventricle. With a premature beat, ...