conclusions prp dressing could significantly decrease the depth and surface area of dfus in a three-week period. background some of the studies confirmed the effectiveness of platelet rich plasma (prp) in the treatment of diabetic foot ulcers (dfu). however, these studies had small sample size and used different methods such as prp gel or prp injections. the results are also contraversial. obje...

background:the aim of this study is to find out the spatial and temporal expression of tgf-b1 during the tendon healing, after application of platelet rich plasma (prp). methods: a patellar tendon defect model in rabbits was used for this purpose. 48 skeletally mature new zealand white rabbits, weighing 3.5 kg, were used for this study. equal numbers of animals from both groups were sacrificed ...

objectives:  the efficacy of adding platelet-rich plasma (prp) to demineralized freeze-dried bone allograft (dfdba) in order to improve the clinical and radiographic results obtained in treatment of deep periodontal intrabony defects has yet to be fully elucidated. materials ­and methods: this double blind, split-mouth randomized controlled clinical trial was conducted on 12 patients with two c...

The formation of thrombi in vivo includes the activation of both platelets and the coagulation cascade. Conventional thrombolytic therapy is primarily directed toward the dissolution of fibrin. To evaluate the possibility that platelet activity impairs the lysis of thrombi, we studied the effects of aspirin and platelet-deaggregating prostaglandin E1 on thrombolysis with urokinase. Combined pla...

Platelet-rich plasma (PRP) has gained growing popularity in the treatment of articular cartilage lesions in the last decade. However, the potential harmful effects of leukocytes in PRP on cartilage regeneration have seldom been studied in vitro, and not at all in vivo yet. The objective of the present study is to compare the effects of leukocyte- and platelet-rich plasma (L-PRP) and pure platel...

Although horizontal tears of the meniscus have historically been treated with partial meniscectomy due to poor vascularity within the tear, evidence suggests that repair of horizontal meniscal tears may be advantageous to partial meniscectomy. Furthermore, the addition of platelet-rich plasma has shown promise in improving meniscal healing. We present our technique of platelet-rich fibrin clot-...

- Knee pathologies including focal cartilage injuries, osteoarthritis (OA), and ligament injuries are common. The poor regeneration and healing potential of cartilage has led to the search for other treatment modalities with improved healing capacity. Furthermore, with an increasing elderly population that desires to remain active, the burden of knee pathologies is expected to increase. Increas...

Objectives: Platelet-rich plasma (PRP) injections have recently become commercially available and are marketed directly to consumers for the treatment of knee osteoarthritis (OA). Anabolic effects from cytokines concentrated in Leukocyte-Poor configurations PRP (LP-PRP) hypothesized inhibit native catabolic environment cartilage degeneration process. Multiple Level I trials comparing LP- hyalur...

Platelet-rich plasma (PRP) is an autologous blood product with platelet concentrations above baseline values. The process involves the extraction of blood from the patient which is then centrifuged to obtain a concentrated suspension of platelets by plasmapheresis. It then undergoes a two-stage centrifugation process to separate the solid and liquid components of the anticoagulated blood. PRP o...