Biogenesis of respiratory chain complexes depends on the expression of mitochondrial-encoded subunits. Their synthesis occurs on membrane-associated ribosomes and is probably coupled to their membrane insertion. Defects in expression of mitochondrial translation products are among the major causes of mitochondrial disorders. Mdm38 is related to Letm1, a protein affected in Wolf-Hirschhorn syndr...

Significance SARS-CoV-2 is the causative agent of COVID-19 pandemic. A molecular framework for how virus manipulates host cellular machinery to facilitate infection needed. Here, we integrate biochemical and single-molecule strategies reveal insight into NSP1 from inhibits translation initiation. directly binds small (40S) subunit human ribosome, which modulated by initiation factors. Further, ...

The scientific review considers the mechanisms of action cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during initiation and post-initiation period translation. To write article, information was searched using Scopus, Web Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, Cochrane Library, CyberLeninka databases. It known that silencing translation occurs...

The ribosome is subjected to post-translational modifications, including phosphorylation, that affect its biological activity. Among ribosomal elements, the P-proteins undergo phosphorylation within C terminus, element which interacts with trGTPases or ribosome-inactivating proteins (RIPs); however, role of has never been elucidated. Here, we probed function on interaction RIPs using P1-P2 dime...

The well established phenomenon of ribosome drop-off plays crucial roles in translational accuracy and nutrient starvation responses during protein translation. When cells are under stress conditions, such as amino acid starvation or aminoacyl-tRNA depletion due to a high level of recombinant protein expression, ribosome drop-off can substantially affect the efficiency of protein expression. He...