Flavin nucleotides are components of certain enzyme systems which are involved in the oxidation of nitrogenous compounds, including at least some of the amino acids. The oldest and best-known evidence for this relationship was derived from studies of biochemical systems in vitro, but it is also supported by the results of studies on intact animals. For example, Burch, Lowry, Padilla & Combs (19...

Riboflavin or vitamin B2 (no. 1), a definite member of the 1 vitamin B complexis a pigment of the flavin type and has the empirical formula C17H20N4O?. It has also been called vitamin G, lactoflavin and ovaflavin. The other vitamin B2 (no. 2)?the P-P factor, nicotinic acid?has the formula C0H4N COOH, and its amide, C6H4N CONH?. Riboflavin has been isolated in pure form from liver, yeast and mil...

AIMS Various studies have shown that plasma homocysteine (HCY) serum levels are elevated in actively drinking alcohol-dependent patients a during alcohol withdrawal, while rapidly declining during abstinence. Hyperhomocysteinemia has been associated not only with blood alcohol concentration (BAC), but also with deficiency of different B-vitamins, particularly folate, pyridoxine and cobalamin. ...

Assessment of nutritional status of vitamin B components by plasma or blood levels indicated riboflavin deficiency and possibly thiamine deficiency in Nigerian patients who suffered from tropical ataxic neuropathy and neurologically normal Nigerians who subsisted on predominant cassava diet. Serum levels of folate, niacin, pyridoxine and panthothenic acid were normal. Vitamin deficiencies proba...

Aims: Various studies have shown that plasma homocysteine (HCY) serum levels are elevated in actively drinking alcohol-dependent patients a during alcohol withdrawal, while rapidly declining during abstinence. Hyperhomocysteinemia has been associated not only with blood alcohol concentration (BAC), but also with deficiency of different B-vitamins, particularly folate, pyridoxine and cobalamin. ...

Young rhesus monkeys (Macaca mulatta) were given a diet containing casein, polished rice, whole wheat, salt mixture, sodium chloride, cod liver oil, and ascorbic acid. They developed a syndrome characterized by anemia, leukopenia, and loss of weight. Ulceration of the gums and diarrhea were common, and death occurred between the 26th and 100th day. 4 monkeys were given the deficient diet supple...

This study was undertaken to determine how flavin enzymes are distributed in different tissues and their fate with riboflavin restriction of greater or lesser severity. Such a study might be expected to uncover differences in metabolic patterns of different tissues and to expose enzymatic defects which must underlie the functional deficits and physical changes of riboflavin deficiency. Tissues ...

BACKGROUND Friedreich ataxia is a neurodegenerative disease caused by the lack of frataxin, a mitochondrial protein. We previously demonstrated that frataxin interacts with complex II subunits of the electronic transport chain (ETC) and putative electronic transfer flavoproteins, suggesting that frataxin could participate in the oxidative phosphorylation. METHODS AND FINDINGS Here we have inv...

The objective of this study was to investigate the effects of riboflavin-deficient and Trichinella spiralis-induced stresses on corticosterone associated with spermatogenesis in male Wistar rats. Rats were allocated into 4 groups: Group 1: control; group 2: riboflavin-deficient diet; group 3: T. spiralis infection; group 4: riboflavin deficient diet with T. spiralis infection. This experiment l...