نتایج جستجو برای: rhoptry

تعداد نتایج: 383  

2017
Nathan M. Chasen Beejan Asady Leandro Lemgruber Rossiane C. Vommaro Jessica C. Kissinger Isabelle Coppens Silvia N. J. Moreno

Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs). These CARPs are found in animals (both vertebrates and invertebrates) and viruses as either independent proteins or domains of other proteins. We report here the identification of a new CARP (TgCA_RP) in the unicellular organism Toxoplas...

2017
Alexandra Miliu Maryse Lebrun Catherine Braun-Breton Mauld H Lamarque

During the erythrocytic cycle of the malaria parasite Plasmodium falciparum, egress and invasion are essential steps finely controlled by reversible phosphorylation. In contrast to the growing number of kinases identified as key regulators, phosphatases have been poorly studied, and calcineurin is the only one identified so far to play a role in invasion. PfShelph2, a bacterial-like phosphatase...

2012
Adam James Reid Sarah J. Vermont James A. Cotton David Harris Grant A. Hill-Cawthorne Stephanie Könen-Waisman Sophia M. Latham Tobias Mourier Rebecca Norton Michael A. Quail Mandy Sanders Dhanasekaran Shanmugam Amandeep Sohal James D. Wasmuth Brian Brunk Michael E. Grigg Jonathan C. Howard John Parkinson David S. Roos Alexander J. Trees Matthew Berriman Arnab Pain Jonathan M. Wastling

Toxoplasma gondii is a zoonotic protozoan parasite which infects nearly one third of the human population and is found in an extraordinary range of vertebrate hosts. Its epidemiology depends heavily on horizontal transmission, especially between rodents and its definitive host, the cat. Neospora caninum is a recently discovered close relative of Toxoplasma, whose definitive host is the dog. Bot...

Journal: :Clinical and vaccine immunology : CVI 2008
Will L Goff Wendell C Johnson John B Molloy Wayne K Jorgensen Susan J Waldron Julio V Figueroa Olivier Matthee D Scott Adams Travis C McGuire Ignacio Pino Juan Mosqueda Guy H Palmer Carlos E Suarez Donald P Knowles Terry F McElwain

A competitive enzyme-linked immunosorbent assay (cELISA) based on a broadly conserved, species-specific, B-cell epitope within the C terminus of Babesia bigemina rhoptry-associated protein 1a was validated for international use. Receiver operating characteristic analysis revealed 16% inhibition as the threshold for a negative result, with an associated specificity of 98.3% and sensitivity of 94...

2012
Jean Semé Fils Alexandre Phonepadith Xangsayarath Morakot Kaewthamasorn Kazuhide Yahata Jetsumon Sattabongkot Rachanee Udomsangpetch Osamu Kaneko

Plasmodium falciparum Clag protein is a candidate component of the plasmodial surface anion channel located on the parasite-infected erythrocyte. This protein is encoded by 5 separated clag genes and forms a RhopH complex with the other components. Previously, a signature of positive diversifying selection was detected on the hypervariable region of clag2 and clag8 by population-based analyses ...

Journal: :Clinical and vaccine immunology : CVI 2006
Xiaohong Huang Xuenan Xuan Rodolfo A Verdida Shoufa Zhang Naoaki Yokoyama Longshan Xu Ikuo Igarashi

An immunochromatographic test for the simultaneous detection of Babesia caballi- and B. equi-specific antibodies (BceICT) was developed using a recombinant B. caballi 48-kDa rhoptry protein (rBc48) and a recombinant truncated B. equi merozoite antigen 2 (rEMA-2t). An evaluation of the ability of the BceICT to detect antibodies in sera from uninfected horses and experimentally infected horses sh...

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