Let $T_{\rho}$ be an irrational rotation on a unit circle $S^{1}\simeq [0,1)$. Consider the sequence $\{\mathcal{P}_{n}\}$ of increasing partitions $S^{1}$. Define hitting times $N_{n}(\mathcal{P}_n;x,y):= \inf\{j\geq 1\mid T^{j}_{\rho}(y)\in P_{n}(x)\}$, where $P_{n}(x)$ is element $\mathcal{P}_{n}$ containing $x$. D. Kim and B. Seo in [9] proved that rescaled $K_n(\mathcal{Q}_n;x,y):= \frac{\...

Angiotensin II enhances the development of atherosclerotic lesion in which cellular proliferation and/or migration are critical steps. Although cyclin-dependent kinase inhibitor, p27, and Rho/Rho-kinase pathway have recently been implicated as factors regulating these events cooperatively, their role in vivo has not been fully elucidated. We evaluated the contribution of p27 and Rho-kinase to a...

rho-kinase is an effector molecule of rhoa, a monomeric gtp-binding protein, and causes ca2+ sensitization through inactivation of myosin phosphatase. the major physiological functions of rho/rho-kinase cascade include contraction, proliferation and migration in cells.there are some excellent reviews about rho/rho-kinase signal pathway, most of which focus on the specific proteins of the pathwa...

The aim of this study was to unravel the molecular pathogenesis of an unusual retinitis pigmentosa (RP) phenotype observed in a Turkish consanguineous family. Homozygosity mapping revealed two candidate genes, SAMD7 and RHO. A homozygous RHO mutation c.448G > A, p.E150K was found in two affected siblings, while no coding SAMD7 mutations were identified. Interestingly, four non-coding homozygous...

Background: Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial glands and stroma surrounded by dense fibrous tissue. Whereas, normal eutopic endometrium shows scarless tissue repair during menstrual cycles, which suggests that the endometriotic tissues have distinct mechanisms of fibrogenesis. During the development of en...

Rho kinase mediates the effects of inflammatory permeability factors by increasing actomyosin-generated traction forces on endothelial adherens junctions, resulting in disassembly of intercellular junctions and increased vascular leakage. In vitro, this is accompanied by the Rho kinase-driven formation of prominent radial F-actin fibers, but the in vivo relevance of those F-actin fibers has bee...

patients and methods this cross-sectional study included a total of 120 adult predialysis ckd patients. forty patients were allocated in each predialysis ckd group of stages 3, 4, and 5. serum ctnt and hs-crp, plasma nt-probnp, and single spot urine albumin creatinine ratio (acr) were measured. ultrasonographic examination of carotid artery was done with 7.5 mhz linear probe in b mode ultrasono...

Villalba N, Stankevicius E, Simonsen U, Prieto D. Rho kinase is involved in Ca entry of rat penile small arteries. Am J Physiol Heart Circ Physiol 294: H1923–H1932, 2008. First published January 25, 2008; doi:10.1152/ajpheart.01221.2007.—Tonic physiological activity of RhoA/Rho kinase contributes to the maintenance of penile flaccidity through its involvement in the Ca sensitization of erectile...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 188 No. 2 271–285 www.jcb.org/cgi/doi/10.1083/jcb.200906089 JCB 271 Correspondence to Armela Joset: [email protected]; or Martin E. Schwab: [email protected] Abbreviations used in this paper: CGN, cerebellar granule neuron; CNS, central nervous system; CREB, cAMP response element binding; db-cAMP, dibutyryl cAMP; DIV, day in vitro; dn...