s and/or oral presentations presented at American College of Rheumatology (ACR) 2010, 2011 and 2012: 1. Pickens SR, Volin MV, Mandelin II AM, Shahrara S. Local expression of IL-27 ameliorate collagen induced arthritis. Arthritis Rheum 714: S298, 2010. Oral presentation 2. Pickens SR, Volin MV, Pope RM, Mandelin II AM, Shahrara S. Characterization of CCR7 and its ligands CCL19 and CCL21 in rheum...

BACKGROUND The prevalence of chronic renal disease exceeds 10% in industrialized societies. Oxidative damage is thought to be one of the main mechanisms involved in nearly all chronic renal pathologies. OBJECTIVE We aimed to use the oxygen radical absorbance capacity (ORAC) method and a sequential multisolvent extraction process to compare the in vitro antioxidant capacity of 55 medicinal her...

The transcription factor hypoxia-inducible factor-1 (HIF-1) consists of oxygen-sensitive HIF-1α and constitutive HIF-1β. HIF-1α is undetectable in normal cells, but cancer cells frequently express HIF-1α to support their growth, angiogenesis, and high glycolysis (also known as the Warburg effect). The Warburg effect in cancer cells increases energy expenditure and thus participates in cancer-in...

Osteosarcoma is the most common primary bone malignancy and primarily occurs in adolescents and young adults. Crude extract of Rheum palmatum L. (CERP) has been used as a traditional Chinese medicine for different diseases and there is experimental evidence that it may have anti-cancer effects. However, there is no information showing that CERP can affect the mobility of human osteosarcoma cell...

BACKGROUND Accumulating evidence has shown that chronic cerebral ischemia (CCI) is one of the major causes of vascular dementia (VD) characterized by dysregulated cholesterol homeostasis and lipoprotein disturbances. Positive value of lipid-lowering agents has been widely evaluated for the treatment of VD. In the present study, we investigated whether Daming capsule (DMC) protected against CCI-...