The physiological correlation between casein kinase I (CK-I) and an isoform eta of protein kinase C (C-kinase eta) was investigated in vitro, since it has been reported that (i) cholesterol-3-sulfate (CH-3S) effectively activates C-kinase eta rather than the other isoforms (C-kinase epsilon and C-kinase delta) in vitro; and (ii) CK-I efficiently phosphorylates CH-3S-binding proteins, such as hi...

Individual giant radio pulses (GRPs) from the Crab pulsar last only a few microseconds. However, during that time they rank among the brightest objects in the radio sky reaching peak flux densities of up to 1500 Jy even at high radio frequencies. Our observations show that GRPs can be found in all phases of ordinary radio emission including the two high frequency components (HFCs) visible only ...

Dear Sir, G antigen (Rh12) is expressed on red blood cells that carry D and/or C antigen1-3. Serine is the critical amino acid for G antigen expression. Anti-G can cause haemolytic disease of newborn, which is rare, but responsible for neonatal morbidity and mortality. However, Anti-G antibody is difficult to distinguish from anti-D in combination with anti-C. Accurate identification of these a...

BACKGROUND No unified method exists to effectively predict and monitor progression of pulmonary arterial hypertension (PAH). We assessed the longitudinal relationship between a novel marker of cardiopulmonary reserve and established prognostic surrogate markers in patients with pulmonary vascular disease. METHODS AND RESULTS Twenty participants with confirmed (n = 14) or at high risk (n = 6) ...

To investigate the genetic basis of the Rh polypeptide gene, we attempted the isolation of cDNA clones for Rh polypeptide from a family with the RhD-positive and RhD-negative phenotypes using the reverse transcription (RT)-PCR method for each reticulocyte RNAs followed by subcloning. The isolated cDNAs showed the existence of another Rh-related clone (RhPII-1 cDNA, tentative designation) beside...

BACKGROUND Federally qualified community health centers (CHCs) and rural health clinics (RHCs) are intended to provide access to care for vulnerable populations. While some research has explored the effects of CHCs on population health, little information exists regarding RHC effects. We sought to clarify the contribution that CHCs and RHCs may make to the accessibility of primary health care, ...

RHC 80267, 1,6-di(O-(carbamoyl)cyclohexanone oxime)hexane, is a potent and selective inhibitor (I5o = 4 CM) of canine platelet diglyceride lipase. This agent had no effect on rat platelet phospholipase C at 300 p~ and only slight activity at 100 BM (15% inhibition) against rat platelet phospholipase Az. In the course of studying the effect of this agent on diglyceride lipase, it was found that ...

Blood Transfus 2007; 5: 50-57 © SIMTI Servizi Srl The Rhesus factor is clinically the most important protein-based blood group system. With 49 antigens so far described, it is the largest of all 29 blood group systems. The unusually large number of Rhesus antigens is attributable to its complex genetic basis. The antigens are located on two Rhesus proteins RhD and RhCE and are produced by diffe...

BACKGROUND There is dearth of evidence on provider cost of contracted out services particularly for Maternal and Newborn Health (MNH). The evidence base is weak for policy makers to estimate resources required for scaling up contracting. This paper ascertains provider unit costs and expenditure distribution at contracted out government primary health centers to inform the development of optimal...