By ALEXANDER S. WIENER, M.D., F.A.C.P., RAFFAELE NAPPI, M.D. AND EVE B. GORDON I N THE PRECEDING PAPER’ our methods for performing Rh antibody titrations were described in detail, with special reference to the precautions taken to insure objective and reproducible results. Using these technics, it was shown that pregnancies with Rh-negative fetuses and the birth of Rh-negative babies have no si...

98 Mexican Indians were tested for the blood properties A-B-O, A(1)-A(2), M-N, P, Rh'-Rh''-Rh(0)-rh, and Hr. Of the 98 Indians, 90.8 per cent belonged to group 0, 6.1 per cent belonged to A(1), and 3.1 per cent to group B. There were 61.2 per cent of type M, 3.1 per cent of type N, and 35.7 per cent of type MN. Of the 95 Mexican Indians tested with anti-P serum, 21.1 per cent were found to lack...

Introduction Industrial higher olefin (> C5) hydroformylation processes require harsh temperatures and pressures (140 200 oC, 5 30 MPa) as well as tedious catalyst separation schemes involving hazardous reagents to recycle the cobalt catalyst [1]. The use of rhodium (Rh) as a catalyst would lower the operating temperature and pressure but requires almost quantitative recovery and recycle of the...

The human Hrs and STAM proteins comprise the ESCRT-0 complex, which sorts ubiquitinated cell surface receptors to lysosomes for degradation. Here we report a model for the complete ESCRT-0 complex based on the crystal structure of the Hrs-STAM core complex, previously solved domain structures, hydrodynamic measurements, and Monte Carlo simulations. ESCRT-0 expressed in insect cells has a hydrod...

Enantioselective hydrogenation of amino ketones catalyzed by Ru– or Rh–phosphine complexes provides an efficient method for the synthesis of enantiomerically active amino alcohols, a class of chiral compounds of great importance in pharmaceutical products. A recent challenging target inspired us to look for a practical solution for the enantioselective reduction of b-amino ketones with a second...

Accumulating data indicate that G12 subfamily (Galpha12/13)-mediated signaling pathways play pivotal roles in a variety of physiological processes, while aberrant regulation of this pathway has been identified in various human diseases. It has been demonstrated that Galpha12/13-mediated signals form networks with other signaling proteins at various levels, from cell surface receptors to transcr...

The physiological mechanism of functional constipation (FC) includes defecatory disorders and delayed colon transit. About 18% to 68% constipated patients may have rectal hyposensitivity (RH). We performed this study to investigate the association between RH and functional defecatory disorder (FDD) as well as that between RH and delayed colon transit in FC patients.A total of 218 FC patients we...

Red blood cell deficiency of Rh proteins is associated with morphologic and functional abnormalities of erythrocytes and with a chronic hemolytic anemia of varying severity. Rh-deficiency may be the result of homozygosity either for a silent allele at the RH locus (Rhnull amorph type) or for a recessive inhibitor gene(s) at an autosomal locus unlinked to RH locus (Rhnull regulator and Rhmod). I...

[1] This study investigates the aerosol humidification effect (AHE) using 70 profiles of the aerosol scattering coefficients at high ( 80%) and low ( 40%) relative humidity (RH) levels and absorption coefficient at a low RH level obtained by a light aircraft (Cessna C-172N) over the Southern Great Plains (SGP) site from April 2003 to June 2004. The column aerosol humidification factor, R(RH), d...