Methotrexate (MTX) is a cornerstone in the treatment of juvenile idiopathic arthritis (JIA). Although associated with many mild adverse effects, the short and long-term safety of MTX in JIA has been excellent. While many JIA children treated with MTX develop liver enzyme abnormalities, no cases of irreversible liver damage or of severe non-infectious hepatitis with Reye-like features have been ...

Carnitine deficiency syndrome is a rare and potentially fatal but treatable metabolic disorder. I present a 6-year-old girl with primary systemic carnitine deficiency (SCD) proved by very low plasma carnitine level. Her major clinical features included neonatal metabolic acidosis, epilepsy, recurrent infections, acute encephalopathy, and dilated cardiomyopathy with heart failure before 4 years ...

Mitochondrial trifunctional protein (MTP) is a hetero-octamer of four alpha and four beta subunits that catalyzes the final three steps of mitochondrial long chain fatty acid beta-oxidation. Human MTP deficiency causes Reye-like syndrome, cardiomyopathy, or sudden unexpected death. We used gene targeting to generate an MTP alpha subunit null allele and to produce mice that lack MTP alpha and be...

This statement was originally published as: The Diagnosis and Treatment of Reye's Syndrome. NIH Consens Statement 1981 Mar 2-4; 4(1):1-15. For making bibliographic reference to the statement in the electronic form displayed here, it is recommended that the following format be used: The Diagnosis and Treatment of Reye's Syndrome. NIH Consens Statement Online 1981 Mar 2-4 [cited year month day]; ...

Crystallographical characterization of nanocrystals PbS doped with Ni Javier Martínez-Juárez,a Oscar Portillo-Moreno,b Melissa ChávezPortillo,a Joel Díaz-Reyes,c Rosendo Lozada-Morales,d and Gabriel Juárez-Díaz,a aPosgrado en Dispositivos Semiconductores, Instituto de Ciencias, BUAP, Puebla, 14 Sur Esquina San Claudio, Ciudad Universitaria Edif. 103 C, C. P. 72570, (Mex). bFCQ, BUAP(Mex), cCIBA...

Of ten patients with Reye's syndrome, there were five with stage II or III coma where EEGs revealed 14 c/sec positive bursts in a background of diffuse delta waves. Positive bursts disappeared upon EEG improvement in two survivors and when the EEG became nearly isoelectric in two other patients. Although 14 and 6 c/sec positive bursts are seen commonly during sleep in normal young persons, thei...

Yumtaax Boucher (Coleoptera: Passalidae) is an endemic genus from the temperate sierras of Mexico and includes six narrowly distributed species. Yumtaax species have been assigned to several genera of Passalidae throughout history, and a phylogenetic approach is necessary to understand species delimitation and interspecific relationships. This study reconstructed the molecular phylogeny of six ...

Serum levels of ornithine carbamyl transferase activities were determined in the acutely ill and convalescent Reye's syndrome patients and in their parents. Acutely ill Reye's syndrome patients had elevated levels of serum ornithine carbamyl transferase activities as compared to those in controls. The convalescent Reye's syndrome patients and their parents had normal levels of serum ornithine c...

Reye's syndrome is an infrequently diagnosed medical condition affecting mainly children. The etiology, epidemiology and natural history of Reye's syndrome have been cloudily written in footnotes of medical books and exotic papers since the initial description in early 1950s. We report here a case of adult Reye's syndrome associated with serologic evidence of parvovirus B19 infection.