We describe an improved Taylor dispersion method for four-component systems, which we apply to measure the main- and cross-diffusion coefficients in an Aerosol OT water-in-oil microemulsion loaded with one of the reactants of the Belousov-Zhabotinsky (BZ) reaction, water(1)/AOT(2)/R(3)/octane(4) system, where R is malonic acid or ferroin. With [H(2)O]/[AOT] = 11.8 and volume droplet fraction ph...

Photophysical processes of ethidium bromide (EB) in homogeneous solutions, micelles, and reverse micelles have been investigated. In acetonitrile, the fluorescence intensity and lifetime of EB are 6.3 ( 0.3 times those in water and 1.25 ( 0.1 times those in acetone. This is attributed to the weaker hydrogen-bond acceptor property of acetonitrile, compared to water and acetone. Addition of water...

BACKGROUND A microemulsion is an effective formulation for improving the oral bioavailability of poorly soluble drugs. In this paper, a water-in-oil (w/o) microemulsion was investigated as a system for enhancing the oral bioavailability of Biopharmaceutic Classification System (BCS) III drugs. METHODS The microemulsion formulation was optimized using a pseudoternary phase diagram, comprising ...

The objective of the present investigation was to develop and evaluate microemulsion based gel for the vaginal delivery of Sertaconazole. The solubility of Sertaconazole in various oils, surfactants and co-surfactants were checked to identify components of the microemulsion. The ternary diagrams were plotted to identify the area of microemulsion existence. Various gelling agents were evaluated ...

The structure-activity relationship of a U-type antimicrobial microemulsion system containing glycerol monolaurate and ethanol at a 1∶1 mass ratio as oil phase and Tween 20 as surfactant were investigated along a water dilution line at a ratio of 80∶20 mass% surfactant/oil phase, based on a pseudo-ternary phase diagram. The differential scanning calorimetry results showed that in the region of ...

OBJECTIVE To investigate the cellular uptake of evodiamine and rutaecarpine in a microemulsion in comparison with aqueous suspensions and tinctures. MATERIALS AND METHODS A microemulsion was prepared using the dropwise addition method. Mouse skin fibroblasts were cultured in vitro to investigate the optimal conditions for evodiamine and rutaecarpine uptake with different drug concentrations a...

Wetting and dewetting are both fundamental modes of motion of liquids on solid surfaces. They are critically important for processes in biology, chemistry, and engineering, such as drying, coating, and lubrication. However, recent progress in wetting, which has led to new fields such as superhydrophobicity and liquid marbles, has not been matched by dewetting. A significant problem has been the...

In the past decade, semiconductor nanoparticles have attracted much attention arising from the fundamental scientific interest in understanding the transition of material properties from the bulk to molecular-like clusters and their potential applications. The main issue in the preparation of semiconductor nanocrystals is a careful control of particle size and, even more important, their size d...