OBJECTIVE To study the frequency of retinal toxicity and associated risk factors in a cohort of patients treated with antimalarials and seen at a tertiary level hospital. MATERIAL AND METHODS Retrospective study of 40 patients treated with antimalarials, who were referred to ophthalmology for the study of retinal toxicity during 2011. Data collection included type of antimalarial prescribed, ...

PURPOSE To report a case of multifocal serous retinal detachments associated with pimasertib. METHODS The authors report a 26-year-old patient who developed bilateral multifocal serous retinal detachments appearing 2 days after starting pimasertib (as part of a clinical trial investigating its use in low-grade metastatic ovarian cancer) and rapidly resolving 3 days after stopping it. CONCLU...

Introduction: Ritonavir as part of Highly Active Antiretroviral Therapy (HAART) is a potent inhibitor HIV protease that have been reported causing retinal impairment in the long term use. Primary eye care (PEC) an integral primary health provides early screening for drug induced toxicity, by using funduscopy examination. This study proposed to review and analyze some case reports conducted on l...

OBJECTIVES To compare different screening procedures for hydroxychloroquine sulfate (Plaquenil) toxicity at different stages of damage. METHODS Ten patients were studied using 10-2 automated fields, multifocal electroretinography, spectral domain optical coherence tomography (SD-OCT), and fundus autofluorescence. RESULTS All 10 patients used hydroxychloroquine for more than 6 years, and tho...

Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase, effectively halting seizures. Unfortunately, VGB treatment is also associated with the highest frequencies of peripheral visual field constriction of any of the antiepileptic drugs and the mechanisms that lead to these visual field defects are uncertain. Recent studies have demonstrated light exp...

In recent years, research on nanoparticles (NPs) has brought a new phase in the development of medicine. The term “NPs” refers to nanoscale particles, typically between 10 and 1,000 nm size, that are within range cellular molecular structures. Compared with traditional ophthalmic drugs, NPs can carry drugs overcome obstacles, target drug delivery, prolong release, reduce toxicity, be used gene ...