BKAGG, P. D., and D. J. RAINNIE. 1974. The effect of silver ions on the respiratory chain of Esclrerichia coli. Can. J. Microbiol. 20: 883-889. Silver ions inhibited the oxidation of glucose, glycerol, fumarate, succinate, Dand L-lactate, and endogenous substrates by intact cell suspensions of Esclrerichia coli. Silver ions reacted with the respiratory chain at two levels. The site nlost sensit...

1. The influence of D20 and organic solvents on the rate of oxidation of added substrates by heart muscle particles and tightly coupled rat liver mitochondria has been investigated. Solvents examined include glycerol, sucrose, dimethyl sulfoxide, dimethyl formamide, and ethylene glycol. Each of these solvents was found to induce a marked inhibition of respiratory chain activity. 2. The relative...

friedreichs ataxia (frda) is an inherited recessive disorder characterized by progressive neurological disability and heart abnormalities. a deficiency in the protein frataxin causes this disease. frataxin deficiency leads to progressive iron accumulation in mitochondria, excessive free radical production and dysfunction of respiratory chain complexes. the expansion (gaa) repeat in the first in...