PURPOSE The purpose of our study was to assess the feasibility, toxicity, and pharmacokinetics of an escalating dose of docetaxel when administered with granulocyte colony-stimulating factor (G-CSF) support every 3 weeks. EXPERIMENTAL DESIGN Patients with advanced solid malignancies were treated with escalating doses of docetaxel as a 1-h infusion every 3 weeks, supported by s.c. administrati...

A hydrophobic grid membrane filtration (HGMF) colony hybridization assay was developed that allows strain-specific differentiation of defined bacterial populations. The randomly amplified polymorphic DNA (RAPD) fingerprinting technique was used to identify potential signature nucleic acid sequences unique to each member of a commercial cheese starter culture blend. The blend consisted of two cl...

The purpose of this descriptive-correlation study was to investigate effective factors on rural people’s non-participation of Mahabad’s dam catchment in Watershed Management Projects. The research instrument was structural questionnaire with close-ended questions, which its validity confirmed by panel of academic staff and reliability of questionnaire was confirmed. The target population of thi...

U6 small nuclear RNA (snRNA), an essential component of the eukaryotic spliceosomes, is unique in that it is ynthesized by RNA polymerase 111, while all other U-snRNAs are synthesized by RNA polymerase 11. U6 genes are notable for functional upstream regulatory elements which resemble RNA polymerase I1 regulatory sequence motifs. In this study, the optimal conditions for transcription of the U6...

Aleurone flour (ALF) is a rich source of natural folate (>500 microg/100 g wet weight). Our objective was to establish whether intake of ALF in man can significantly improve folate status and reduce plasma homocyst(e)ine. We performed a randomised, controlled intervention, of 16 weeks duration, in free-living healthy individuals (mean age 46-52 years). Participants were assigned to one of three...

In this study, marine tunicate Styela clava hydrolysate was produced by an environment friendly and green technology, pressurized hot water hydrolysis (PHWH) at different temperatures (125–275 °C) and pressure 50 bar. A wide range of physico-chemical and bio-functional properties such as color, pH, protein content, total carbohydrate content, reducing sugar content, and radical scavenging activ...