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Several studies have examined the link between the cannabinoid CB1 receptor and several neuropsychiatric illnesses, including schizophrenia. As such, there is a need for in vivo imaging tracers so that the relationship between CB1 and schizophrenia (SZ) can be further studied. In this paper, we present our first human studies in both healthy control patients and patients with schizophrenia usin...
Abstract Purpose Accelerated soil erosion poses a global hazard to health. Understanding and sediment behaviour through fingerprinting enables the monitoring identification of areas with high delivery. Land-use specific source apportionment is increasingly determined using Bayesian mixing model MixSIAR compound-specific stable isotopes (CSSI). Here, we investigate CSSIs fatty acid (FA) tracer s...
For programmers seeking to familiarize themselves with the component of the C++11 standard library, we provide background information and tutorial guidance with numerous usage examples.
Abstract Purpose In the last years, role of PET imaging in assessment cerebral amyloid angiopathy (CAA) is emerging. this setting, some tracers have proven their utility for evaluation disease (mainly 11 C-Pittsburgh compound B [ C-PIB]), however, value other radiotracers has to be clarified. The aim systematic review is, therefore, assess CAA. Methods A wide literature search PubMed/MEDLINE, S...
Sediment fingerprinting experiments have been used to demonstrate the sensitivity of numerical mixing model outputs different particle size distributions in source materials and experimental sediment mixtures. The study aims examine further grain effects distribution geochemical elements by soils through a laboratory experiment simulating sorting processes, investigate if fractions are influenc...
BACKGROUND Histamine H3 receptor (H3R) is a potential therapeutic target of sleep- and cognition-related disorders. The purpose of the present study is to develop a novel positron emission tomography (PET) ligand for H3Rs from dihydroquinolinone derivatives, which we previously found to have high affinity with these receptors. METHODS Six compounds were selected from a dihydroquinolinone comp...
It is important to gain more insight into neurodegenerative diseases, because these debilitating diseases can not be cured. A common characteristic of many neurological diseases is neuroinflammation, which is accompanied by the presence of activated microglia cells. In activated microglia cells, an increase in the expression of peripheral benzodiazepine receptors (PBR) can be found. The PBR was...
As part of the Deep Convective Cloud and Chemistry (DC3) experiment, the National Science Foundation/National Center for Atmospheric Research (NCAR) Gulfstream-V (GV) and NASA DC-8 research aircraft probed the chemical composition of the inflow and outflow of two convective storms (north storm, NS, south storm, SS) originating in the Colorado region on 22 June 2012, a time when the High Park wi...
Due to high noise levels in the voxel kinetics, development of reliable parametric imaging algorithms remains one of most active areas in dynamic brain PET imaging, which in the vast majority of cases involves receptor/transporter studies with reversibly binding tracers. As such, the focus of this work has been to develop a novel direct 4D parametric image reconstruction scheme for such tracers...
UNLABELLED Spinocerebellar ataxia type 17 (SCA17) is a rare autosomal dominantly inherited neurodegenerative disorder presenting with a variable phenotype including ataxia, dystonia, chorea, and parkinsonism, as well as cognitive impairment. We evaluated morphologic and functional imaging characteristics to elucidate evidence of neurodegeneration in SCA17, even in the presymptomatic stage of th...
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