Opt imum killing of gram-negative bacteria in serum requires the participation of terminal components of the complement system, presumably through formation of a membrane attack complex (MAC) 1 containing complement components C5b6789 (13). Although it is clear that some gram-negative bacteria are highly resistant to serum killing in the presence of adequate antibody, the mechanism of this resi...

Background The introduction of HAART has significantly prolonged the life span of HIV-infected patients. However, the error-prone nature of HIV-1 reverse transcriptase (HIV-1 RT) results in the emergence of drug-resistant viruses and threatens the effectiveness of HAART. HIV-1 RT is a primary target of two classes of drugs: nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside ...

Due to their lack of toxicity to mammalian cells and good serum stability, proline-rich antimicrobial peptides (PR-AMPs) have been proposed as promising candidates for the treatment of infections caused by antimicrobial-resistant bacterial pathogens. It has been hypothesized that these peptides act on multiple targets within bacterial cells, and therefore the likelihood of the emergence of resi...

Cisplatin, a small-molecule platinum compound, is one of the most effective broadspectrum anticancer drugs. in the clinic, patients usually have a good initial response to cisplatin-based chemotherapy but later relapse because of the development of cisplatin resistance. This resistance is either acquired or intrinsic and markedly reduces the drug’s clinical effectiveness. At the moment, this co...

Quinolones are potent antibacterial agents that specifically target bacterial DNA gyrase and topoisomerase IV. Widespread use of these agents has contributed to the rise of bacterial quinolone resistance. Previous studies have shown that quinolone resistance arises by mutations in chromosomal genes. Recently, a multiresistance plasmid was discovered that encodes transferable resistance to quino...

the blending of nr and br rubber blend with n330 carbon black is studied on curing behavior and the physico-mechanical properties of a sbr rubber based tire tread compound containing n234 carbon black. the effect of sulphur and accelerator contents on different properties of rubber compound is also tested with a wide range of curing agents. partial substitution of sbr with nr shows significant ...

As the turbine industries need to manufacture turbine blades made of martensitic stainless steel AISI 420 with high toughness and wear resistance, local laser hardening has become more and more important. In this research, surface of the samples was initially hardened by high-power pulsed laser beam; then, optimum parameters of hardening were calculated and wear resistance of surface hardened s...

an investigation was carried out on permethrin-susceptible and resistant strain of malaria vector, an.stephensi. efficacy of several pyrethroids such as permetrhrin, deltamethrin, lambdacyhalothrin, cypermethrin and cyfluthrin against this species showed that those with an α-cyano group and dibromo substitutions were more toxic to sensitive strains than the other classes like permethrin. the ra...