Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to the development of improved whole organism screens, the success of RNA interference (RNAi) in schistosomes offers great promise for the identification of potential drug targets to initiate drug discovery. In this study we set out to contri...

Obesity is associated with vascular diseases that are often attributed to vascular oxidative stress. We tested the hypothesis that vascular oxidative stress could induce obesity. We previously developed mice that overexpress p22phox in vascular smooth muscle, tg(sm/p22phox), which have increased vascular ROS production. At baseline, tg(sm/p22phox) mice have a modest increase in body weight. Wit...

The contribution of respiratory muscle work to the development of the slow component is a point of controversy since it has been shown that the increased ventilation in hypoxia is not associated with a concomitant increase in V slow component. The first purpose of this study was thus to test the hypothesis of a direct relationship between respiratory muscle work and slow component by manipulati...

Models of the active cochlea build upon the underlying passive mechanics. Passive cochlear mechanics is based on physical and geometrical properties of the cochlea and the fluid-tissue interaction between the cochlear partition and the surrounding fluid. Although the fluid-tissue interaction between the basilar membrane and the fluid in scala tympani (ST) has been explored in both active and pa...

ABSTRACT Physical activity is known to influence and regulate leptin hormone secretion, which assists in the regulation of body weight and energy homeostasis. The purpose of the present study was to investigate the effects of a single session of concurrent exercise on leptin levels and insulin resistance, until 24 h post-exercise. Ten male subjects (22.9±1.7 years) healthy volunteer perf...

Previous studies have shown that creatine supplementation reduces muscle damage and inflammation following running but not following high-force, eccentric exercise. Although the mechanical strain placed on muscle fibers during high-force, eccentric exercise may be too overwhelming for creatine to exert any protective effect, creatine supplementation may protect skeletal muscle stressed by a res...