Objective: Several studies have shown that Chichorium intybus L. (C. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. Contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. The aim of the present study was to investigate the effect of aqueous extra...

Objective(s):Acute kidney injury (AKI), a syndrome characterized by decreased glomerular filtration, occurs in every 1 of 5 hospitalized patients.  Renal ischemia-reperfusion, one of the main causes of AKI, is of particular importance in the setting of kidney transplantation. Materials and Methods: Sixty male rats were divided into four groups including control, nephrectomy, sham surgery and re...

background: the role of nitric oxide (no) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all.    objective: to investigate the role of no of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, l-name, a non selective no synthase inhibit...

Renal ischemia–reperfusion (IR) is inevitable in partial nephrectomy and kidney transplantation. Acute tubular necrosis (ATN) induced by renal IR causes the loss of functional units kidney, pathologically presenting as nonhomogeneous distribution normal uriniferous tubules usually used to characterize activity. Optical coherence tomography (OCT) has been proven have ability image microstructure...

Controlled reperfusion by monitoring the blood pressure, flow, and specific parameters during extracorporeal after cardiac arrest has potential to limit ischemia–reperfusion injury. The intracellular calcium overload as part of injury provides possibility for be counteracted early suppression serum with aim improving survival neurological outcome. We investigated effects prolonged via sodium ci...

Introduction: Liver ischemia/reperfusion (IR) is a major clinical problem, which occurs during several conditions such as liver damage, trauma and transplantation. Recent studies indicate that IR-induced acute liver failure causes injuries of distant organs such as heart and lungs by systematic inflammatory responses. Therefore, in the present study, effects of hepatic IR induction were stud...

Background and aim: Acute kidney injury (AKI) is a frequent complication of kidney failure with high mortality which leads to brain dysfunction. The aim of this study was to investigate the possible protective effect of ischemic postconditioning (IPo) against brain dysfunction induced by bilateral renal ischemia (BRI). Materials and methods: Male Wistar rats underwent BRI, sham or IPo surgery ...

background: the role of renin angiotensin system (ras) in ischemic/reperfusion (i/r) injuries is not fully elucidated. furthermore, it is not clear whether inhibition of ras by angiotensin-converting enzyme (ace) inhibitors has beneficial effects in terms of protecting the brain from i/r injuries. in this study enalapril is used as an ace inhibitor to evaluate the role of ras in i/r injuries in...