Reducing the number of host-vector interactions is an effective way to reduce the spread of vector-borne diseases. Repellents are widely used to protect humans from a variety of protozoans, viruses, and nematodes. DEET (N,N-Diethyl-meta-toluamide), a safe and effective repellent, was developed during World War II. Fear of possible side effects of DEET has created a large market for "natural" DE...

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BACKGROUND DEET, 2-undecanone (2-U), IR3535 and Picaridin are widely used as insect repellents to prevent interactions between humans and many arthropods including mosquitoes. Their molecular action has only recently been studied, yielding seemingly contradictory theories including odorant-dependent inhibitory and odorant-independent excitatory activities on insect olfactory sensory neurons (OS...

Plants produce insect repellents, such as citronellal, which is the main component of citronellal oil. However, the molecular pathways through which insects sense botanical repellents are unknown. Here, we show that Drosophila use two pathways for direct avoidance of citronellal. The olfactory coreceptor OR83b contributes to citronellal repulsion and is essential for citronellal-evoked action p...

Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbenzamide) is a 6-decade-old synthetic repellent, which is still considered the gold standard of mosquito repellents. Mosquitoes use their sense of smell to detect DEET, but there are currently two h...

A model was developed using 167 carboxamide derivatives, from the United States Department of Agriculture archival database, that were tested as arthropod repellents over the past 60 yr. An artiÞcial neural network employing CODESSA PRO descriptors was used to construct a quantitative structure-activity relationship model for prediction of novel mosquito repellents. By correlating the structure...

The mission to make humans less attractive to mosquitoes has fuelled decades of scientific research on mosquito behaviour and control. The search for the perfect topical insect repellent/killer continues. This analysis was conducted to review and explore the scientific information on toxicity produced by the ingredients/contents of a herbal product. In this process of systemic review the follow...

Thirteen-lined ground squirrels (Spermophilus tridecemlineatus) and other small rodents damage corn (Zea mays) stands by digging and consuming planted seeds and young seedlings, particularly in reduced-tillage fields. The use of reduced-tillage systems such as ecofarming provides greater dryland crop yields, conserves moisture, reduces soil erosion and provides suitable habitat for ground-nesti...

background: fleas are important vectors of human and animal disease, and control measures for protection against their bites and flea-borne diseases are necessary. methods : the essential oils (eos) of four native medicinal plants, ziziphora tenuiore , myrtus communis , achillea wilhelmsii and mentha piperita were isolated by hydrodistillation technique and analyzed by gc-mc. the repellent acti...

Catmint oil and hydrogenated catmint oil were evaluated as repellents for adult Tribolium casteneum (Herbst) (Coleoptera: Tenebrionidae), the red flour beetle, and T. confusum (DuVal), the confused flour beetle, using both a traditional method of visual assessment of distribution and a video recording method to determine movement patterns of individual insects. Visual assessments of distributio...