نتایج جستجو برای: renal uptake

تعداد نتایج: 369811  

2016
Ho Sze Chan Mark W. Konijnenberg Tamara Daniels Monique Nysus Mehran Makvandi Erik de Blois Wouter A. Breeman Robert W. Atcher Marion de Jong Jeffrey P. Norenberg

BACKGROUND Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological protection can reduce renal uptake of radiopeptides, e.g., positively charged a...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تبریز 1388

اخیرا یک سری تحقیقات دامنه داری در زمینه ی تاثیرات پیچیدگی فعلیت محور(task complexity) بر روی تولید کلامی در قالب "صحت"ء "روانی" و "پیچیدگی" گفتار صورت گرفته است. هر چند تاثیرات "پیچیدگی فعلیت محور" برتعامل کلامی و "واکنش فراگیربه بازخورد تصحیح گر"(learner uptake) به ندرت مورد تحقیق قرار گرفته است. به منظور بررسی تاثیرات فعلیت محور بر روی واکنش فراگیر به بازخورد تصحیح گر 38زبان آموز مذکر در سطح...

2013
Stine S Pedersen Anna K Keller Marie K Nielsen Bente Jespersen Lise Falborg Jan T Rasmussen Christian W Heegaard Michael Rehling

BACKGROUND The purpose of the present study was to quantify renal cell injury after ischemia and reperfusion in a pig model using (99m)Tc-lactadherin as a marker of apoptosis and (99m)Tc-sestamibi as a marker of mitochondrial dysfunction. METHODS Thirty-four pigs were randomized into unilateral renal warm ischemia of 120 (WI120) or 240 min (WI240). The glomerular filtration rate (GFR) was cal...

Journal: :Journal of Biological Chemistry 1972

Journal: :iranian journal of pharmaceutical research 0
danial shamshirian department of radiopharmacy, school of pharmacy, tehran university of medical sciences, tehran, iran mostafa erfani radiation application research school, nuclear science and technology research institute (nstri), tehran, iran davood beiki research center for nuclear medicine, tehran university of medical sciences, tehran, iran maliheh hajiramazanali department of radiopharmacy, school of pharmacy, tehran university of medical sciences, tehran, iran. babak fallahi research center for nuclear medicine, tehran university of medical sciences, tehran, iran

melanocortin-1 (mc1) receptor is an attractive melanoma-specific target for the development of α-msh peptide based imaging and therapeutic agents. in this work a new lactam bridge α-msh analogue was synthesized and radiolabeled with 99mtc via hynic chelator and tricine as co-ligand. also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

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