Vesicoureteral reflux (VUR) has been linked to recurrent urinary tract infections (UTIs), renal scarring, hypertension, renal insufficiency and end-stage kidney disease. Different imaging strategies have been proposed to approach children presenting with UTI to sort out patients with significant VUR while minimizing patient morbidity, radiation exposure and financial burden. None of these imagi...

PURPOSE Limited studies suggest a relationship between scarring on renal scan and failure to resolve vesicoureteral reflux. We evaluated the impact of abnormal renal scans on early vesicoureteral reflux resolution. MATERIALS AND METHODS The medical records and renal scans were reviewed of children diagnosed with primary reflux between 1988 and 2004. We defined an abnormal renal scan as renal ...

Newcastle Asymptomatic Bacteriuria Research Group (1975). Archives of Disease in Childhood, 50, 90. Asymptomatic bacteriuria in schoolchildren in Newcastle upon Tyne. A screening survey for asymptomatic bacteriuria (ASB) in 13 464 schoolgirls aged 4 to 18 years in Newcastle upon Tyne showed an overall prevalence of 1 *9%. In girls aged 4 to 6 years it was 1 4%, in girls aged 7 to 11 years it wa...

Rolleston, G. L., Maling, T. M. J., and Hodson, C. J. (1974). Archives of Disease in Childhood, 49, 531. Intrarenal reflux and the scarred kidney. The incidence and significance of intrarenal reflux (pyelotubular backflow) occurring during micturating cystourethrography has been studied in 386 examinations on patients with vesicoureteric reflux. This phenomenon has not been observed in patients...

The histories and imaging results are presented in 10 children in whom errors had been made in the interpretation of early investigations. Ultrasonography may not detect either vesicoureteric reflux (VUR) or renal scars or inflammation. The reduced nephrogram or renal swelling following a first attack of acute pyelonephritis may not be recognised without renal measurement on an intravenous urog...

Recent advances in pediatric urinary tract imaging include development of alternative imaging methods without use of ionizing radiation; evolving understanding of the relationship of urinary tract infection, vesicoureteral reflux, and renal scarring, including the important role of dysfunctional voiding; development of a consensus nomenclature and risk-based classification for fetal and antenat...

An adolescent with a history of pyelonephritis and renal scarring had antireflux surgery at the age of 2.5 years. His serum creatinine was high at the age of 14 years (133 micromol/l; glomerular filtration rate (GFR) 56 ml/min x 1.73 m(2)), and reflux nephropathy with chronic renal failure was diagnosed. Because of a fall in height velocity, endocrinological investigations were performed six mo...

BACKGROUND Urinary tract infections (UTIs) cause end-stage renal disease (ESRD) but the molecular mechanisms have remained unclear. Recently, the interleukin (IL)-8 receptor was shown to control disease susceptibility in mice and low IL-8 receptor expression was observed in pyelonephritis-prone patients. METHODS Intravesical Escherichia coli infection was established in mIL-8Rh-/- or Balb/c c...

Introduction: This study investigated whether renal and bladder ultrasonography (RBUS) findings performed in children with the first incidence of febrile urinary tract infection (UTI) can predict UTI recurrence, high-grade vesicoureteral reflux (high-grade VUR), or acquired renal scarring (aRS). Methods: In all, 917 children who were admitted to our hospital from January 2001 to October 2010, o...

To The Editor: Pediatric UTI often remains an underdiagnosed clinical entity in primary care [1]. Usually, the presentation of UTI is variable with nonspecific signs and symptoms. But it is important to diagnose the condition as it could be the first presentation of an underlying urological anomaly [2] or it may in itself, lead to significant morbidity from renal scarring, hypertension or event...